Enhancing effect of aminotriazole on paraquat toxicity in vivo

K. Barabás, G. Berencsi, L. Szabó, Sz I. Varga, B. Matkovics

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. 1. The lethal joint action of aminotriazole and the LD50 of paraquat was observed in experimental mice. 2. 2. The molecular mechanism of the synergistic effect may be explained on an experimental basis by the extensive changes in the lipid peroxidation and the cytochrome P-450 activities. 3. 3. Both substances act on the other enzyme activities examined, primarily the catalase activity, in accordance with the literature evidence.

Original languageEnglish
Pages (from-to)569-572
Number of pages4
JournalGeneral Pharmacology
Volume11
Issue number6
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Pharmacology

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