Enhancement of the penetration of dithranol and increase of effect of dithranol on the skin by liposomes

W. Gehring, M. Ghyczy-, M. Gloor, T. Scheer, J. Roding

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An assessment was made in healthy skin of dithranol erythema caused by a 10-min occlusive application of 0.5% dithranol (CAS 1143-38-0) in liposomal gel (Natipide® II) with and without the addition of 3% salicylic acid, and of 0.5% dithranol in vaseline and in a removable standard ointment base, both with 3% salicylic acid. Both liposomal preparations led to a significant potentiation of the dithranol erythema. The results indicate a strong promotion of the penetration of dithranol by the liposomal gel.

Original languageEnglish
Pages (from-to)983-985
Number of pages3
JournalArzneimittel-Forschung
Volume42
Issue number7
Publication statusPublished - 1992

Fingerprint

Anthralin
Liposomes
Skin
Salicylic Acid
Erythema
Gels
Ointment Bases
Petrolatum

Keywords

  • antipsoriatics
  • CAS 1143-38-0
  • dithranol, clinical studies, liposomal gel, skin penetration
  • erythema
  • liposomes
  • Natipide®

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Enhancement of the penetration of dithranol and increase of effect of dithranol on the skin by liposomes. / Gehring, W.; Ghyczy-, M.; Gloor, M.; Scheer, T.; Roding, J.

In: Arzneimittel-Forschung, Vol. 42, No. 7, 1992, p. 983-985.

Research output: Contribution to journalArticle

Gehring, W. ; Ghyczy-, M. ; Gloor, M. ; Scheer, T. ; Roding, J. / Enhancement of the penetration of dithranol and increase of effect of dithranol on the skin by liposomes. In: Arzneimittel-Forschung. 1992 ; Vol. 42, No. 7. pp. 983-985.
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