Enhancement of synaptic strength in the somatosensory cortex following nerve injury does not parallel behavioural alterations

I. Világi, G. Bárdos, K. Dénes, B. Farkas, P. Friedrich

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Following infraorbital nerve transection, underlying mechanisms of the altered synaptic strength were studied in rat barrel cortex slice experiments. In addition to the in vitro electrophysiological studies, open-field tests were run to detect possible behavioural changes associated with cortical oversensitization. Enhanced NMDA receptor-mediated component of the evoked field response appeared in the barrel cortex after nerve injury. The alteration was transient, very distinct on the first day following injury, and almost returned to normal level by the end of the second week. Behavioural changes had not followed this time-course since long-lasting alterations were detected in the open-field test. These observations are in agreement with findings that showed biphasic regenerative processes following nerve injuries in other cortical areas.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalBrain Research Bulletin
Volume64
Issue number6
DOIs
Publication statusPublished - Jan 30 2005

Keywords

  • Barrel cortex
  • Behaviour
  • Excitatory amino acid receptors
  • Open-field
  • Rat
  • Regeneration
  • Synaptic strength

ASJC Scopus subject areas

  • Neuroscience(all)

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