Enhancement of NMDA responses by β-amyloid peptides in the hippocampus in vivo

Zsolt Molnár, Katalin Soós, Imre Lengyel, Botond Penke, Viktor Szegedi, Dénes Budai

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The effects of Alzheimer's disease-related beta-amyloid (Aβ) peptides on the N-methyl-D-aspartate (NMDA)-evoked cell firing rate were studied in hippocampal CA1 neurons of the rat. Extracellular single-unit recordings were combined with iontophoretic applications that allowed quantitative analyses of the interactions between Aβ peptides and NMDA receptor-mediated events in vivo. The NMDA responses were significantly increased both by the full length Aβ1-42 and by its model fragment Aβ25-35. Enhancements of the NMDA responses by the Aβ peptides lasted about 15 min and were irreversible. The effects of Aβ25-35 were prevented by the pentapeptide Lys-Leu-Val-Gly-Phe- amide (KLVGF) and were not evoked when its reversed sequence (Aβ35-25) was applied.

Original languageEnglish
Pages (from-to)1649-1652
Number of pages4
JournalNeuroreport
Volume15
Issue number10
DOIs
Publication statusPublished - Jul 19 2004

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Keywords

  • Alzheimer's disease
  • Amyloid fragment
  • Amyloid β-peptide
  • Microiontophoresis
  • NMDA
  • Rat
  • Single-unit recording

ASJC Scopus subject areas

  • Neuroscience(all)

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