Enhancement of myocardial and vascular function after phosphodiesterase-5 inhibition in a rat model

Sivakkanan Loganathan, Tamás Radovits, Sevil Korkmaz, Kristóf Hirschberg, Enikö Barnucz, Alexander Weymann, Timo Bömicke, Rawa Arif, Matthias Karck, Gábor Szabó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Recent studies have shown the potential of PDE-5 inhibition on acute and chronic heart failure. Nevertheless it remained unclear, how far load-reducing properties and direct effects onmyocardial contractility are responsible for these observations. In the present study, we investigated the effects of vardenafil onmyocardial contractility and vascular function in a dose-response study. Methods: We performed left ventricular pressure-volume analysis in young adult rats by using a Millar microtip conductance catheter. Pressure-volume loops were recorded before and after intravenous injection of vardenafil (3, 10, 30, 100, 300 μg/kg, n = 6/group). Results: Treatment with vardenafil resulted in a significant (p < 0.05) increase in the load-independent cardiac contractility parameters reaching its maximum at the dose of 100μg/kg (ESPVR: 2.15 ± 0.15 vs. 3.29 ± 0.26 mm Hg/μL; PRSW: 93.28 plusmn; 4.04 vs. 134.90 ± 6.27 mm Hg; peak positive dP/dt/EDV: 38.73 ± 7.97 vs. 53.02 ± 3.74 mm Hg·s -1·μL -1; before versus after 100 μg/kg vardenafil). Results of the in vitro organ-bath experiments showed an augmented vasorelaxation of precontracted aortic rings after vardenafil treatment. Conclusion: Our data supports the hypothesis that the usage of vardenafil as "inodilators" could have beneficial effects in heart failure patients.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalThoracic and Cardiovascular Surgeon
Volume60
Issue number4
DOIs
Publication statusPublished - Jun 21 2012

Keywords

  • Cardiac function
  • Contractility
  • Heart failure
  • Pde-5 inhibition

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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