Enhanced responsiveness of lactotrophs in ectopic pituitaries to bromocryptine and estrone acetate

D. J. McComb, E. Horvath, K. Kovacs, N. Ryan, I. Domokos, F. László

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Intrasellar and transplanted pituitaries removed from the same rats were studied using light microscopy, immunocytology, electon microscopy and ultrastructural morphometry following treatment with bromocryptine and/or estrone acetate. Ectopic lactotrophs of rats treated with bromocryptine showed an increase in storage granule size and number, which was not observed in the lactotrophs of corresponding intrasellar pituitaries. In lactotrophs of intrasellar and ectopic pituitaries, treatment with estrone acetate caused a decrease of storage granule size, while rough endoplasmic reticulum (RER) and Golgi region volume density increased. When rats were treated with a combination of bromocryptine and estrone acetate, intrasellar lactotrophs exhibited increased volume density and diameter size in forming granules as well as increased RER volume density. In ectopic lactotrophs, combined treatment led to a decrease in RER, volume densities of Golgi region and forming granules, as well as increased storage granule size. It can be concluded that ectopic lactotrophs were more sensitive to the inhibiting effects of bromocryptine treatment than intrasellar lactotrophs. Intrasellar lactotrophs were more susceptible to estrone acetate than bromocryptine treatment. As a result, the increased responsiveness of ectopic lactotrophs to estrone acetate was less conspicuous.

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalActa Anatomica
Volume110
Issue number2
Publication statusPublished - 1981

Fingerprint

Lactotrophs
Bromocriptine
Rough Endoplasmic Reticulum
Microscopy
acetoxyestrone
Light

ASJC Scopus subject areas

  • Anatomy

Cite this

McComb, D. J., Horvath, E., Kovacs, K., Ryan, N., Domokos, I., & László, F. (1981). Enhanced responsiveness of lactotrophs in ectopic pituitaries to bromocryptine and estrone acetate. Acta Anatomica, 110(2), 113-120.

Enhanced responsiveness of lactotrophs in ectopic pituitaries to bromocryptine and estrone acetate. / McComb, D. J.; Horvath, E.; Kovacs, K.; Ryan, N.; Domokos, I.; László, F.

In: Acta Anatomica, Vol. 110, No. 2, 1981, p. 113-120.

Research output: Contribution to journalArticle

McComb, DJ, Horvath, E, Kovacs, K, Ryan, N, Domokos, I & László, F 1981, 'Enhanced responsiveness of lactotrophs in ectopic pituitaries to bromocryptine and estrone acetate', Acta Anatomica, vol. 110, no. 2, pp. 113-120.
McComb, D. J. ; Horvath, E. ; Kovacs, K. ; Ryan, N. ; Domokos, I. ; László, F. / Enhanced responsiveness of lactotrophs in ectopic pituitaries to bromocryptine and estrone acetate. In: Acta Anatomica. 1981 ; Vol. 110, No. 2. pp. 113-120.
@article{444db8046ddd45278527c668dc1c52be,
title = "Enhanced responsiveness of lactotrophs in ectopic pituitaries to bromocryptine and estrone acetate",
abstract = "Intrasellar and transplanted pituitaries removed from the same rats were studied using light microscopy, immunocytology, electon microscopy and ultrastructural morphometry following treatment with bromocryptine and/or estrone acetate. Ectopic lactotrophs of rats treated with bromocryptine showed an increase in storage granule size and number, which was not observed in the lactotrophs of corresponding intrasellar pituitaries. In lactotrophs of intrasellar and ectopic pituitaries, treatment with estrone acetate caused a decrease of storage granule size, while rough endoplasmic reticulum (RER) and Golgi region volume density increased. When rats were treated with a combination of bromocryptine and estrone acetate, intrasellar lactotrophs exhibited increased volume density and diameter size in forming granules as well as increased RER volume density. In ectopic lactotrophs, combined treatment led to a decrease in RER, volume densities of Golgi region and forming granules, as well as increased storage granule size. It can be concluded that ectopic lactotrophs were more sensitive to the inhibiting effects of bromocryptine treatment than intrasellar lactotrophs. Intrasellar lactotrophs were more susceptible to estrone acetate than bromocryptine treatment. As a result, the increased responsiveness of ectopic lactotrophs to estrone acetate was less conspicuous.",
author = "McComb, {D. J.} and E. Horvath and K. Kovacs and N. Ryan and I. Domokos and F. L{\'a}szl{\'o}",
year = "1981",
language = "English",
volume = "110",
pages = "113--120",
journal = "Cells Tissues Organs",
issn = "1422-6405",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Enhanced responsiveness of lactotrophs in ectopic pituitaries to bromocryptine and estrone acetate

AU - McComb, D. J.

AU - Horvath, E.

AU - Kovacs, K.

AU - Ryan, N.

AU - Domokos, I.

AU - László, F.

PY - 1981

Y1 - 1981

N2 - Intrasellar and transplanted pituitaries removed from the same rats were studied using light microscopy, immunocytology, electon microscopy and ultrastructural morphometry following treatment with bromocryptine and/or estrone acetate. Ectopic lactotrophs of rats treated with bromocryptine showed an increase in storage granule size and number, which was not observed in the lactotrophs of corresponding intrasellar pituitaries. In lactotrophs of intrasellar and ectopic pituitaries, treatment with estrone acetate caused a decrease of storage granule size, while rough endoplasmic reticulum (RER) and Golgi region volume density increased. When rats were treated with a combination of bromocryptine and estrone acetate, intrasellar lactotrophs exhibited increased volume density and diameter size in forming granules as well as increased RER volume density. In ectopic lactotrophs, combined treatment led to a decrease in RER, volume densities of Golgi region and forming granules, as well as increased storage granule size. It can be concluded that ectopic lactotrophs were more sensitive to the inhibiting effects of bromocryptine treatment than intrasellar lactotrophs. Intrasellar lactotrophs were more susceptible to estrone acetate than bromocryptine treatment. As a result, the increased responsiveness of ectopic lactotrophs to estrone acetate was less conspicuous.

AB - Intrasellar and transplanted pituitaries removed from the same rats were studied using light microscopy, immunocytology, electon microscopy and ultrastructural morphometry following treatment with bromocryptine and/or estrone acetate. Ectopic lactotrophs of rats treated with bromocryptine showed an increase in storage granule size and number, which was not observed in the lactotrophs of corresponding intrasellar pituitaries. In lactotrophs of intrasellar and ectopic pituitaries, treatment with estrone acetate caused a decrease of storage granule size, while rough endoplasmic reticulum (RER) and Golgi region volume density increased. When rats were treated with a combination of bromocryptine and estrone acetate, intrasellar lactotrophs exhibited increased volume density and diameter size in forming granules as well as increased RER volume density. In ectopic lactotrophs, combined treatment led to a decrease in RER, volume densities of Golgi region and forming granules, as well as increased storage granule size. It can be concluded that ectopic lactotrophs were more sensitive to the inhibiting effects of bromocryptine treatment than intrasellar lactotrophs. Intrasellar lactotrophs were more susceptible to estrone acetate than bromocryptine treatment. As a result, the increased responsiveness of ectopic lactotrophs to estrone acetate was less conspicuous.

UR - http://www.scopus.com/inward/record.url?scp=0019469043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019469043&partnerID=8YFLogxK

M3 - Article

C2 - 7331745

AN - SCOPUS:0019469043

VL - 110

SP - 113

EP - 120

JO - Cells Tissues Organs

JF - Cells Tissues Organs

SN - 1422-6405

IS - 2

ER -