Enhanced accumulation of pericardial fluid adenosine and inosine in patients with coronary artery disease

Levente Fazekas, F. Horkay, V. Kékesi, E. Huszár, E. Barát, Réka Fazekas, Tamás Szabó, A. Juhász-Nagy, Attila Naszlady

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Adenosine and inosine are believed to have cardioprotective effects. However, little is known about their possible role in the metabolic autoregulation of human coronaries and in pathologic conditions with supply/demand imbalance of the heart such as coronary artery disease. Since these low molecular weight nucleosides freely diffuse through the monolayer of the visceral pericardium, adenosine and inosine concentrations in pericardial fluid may well reflect the conditions in cardiac interstitium. The pericardial fluid and systemic venous blood adenosine and inosine concentrations were measured in 98 human subjects undergoing heart surgery for coronary artery disease or valvular heart disease. Adenosine and inosine concentrations were measured by HPLC with UV detection. In subjects with coronary artery disease pericardial fluid nucleoside concentrations were significantly higher than in patients with valvular heart disease (adenosine: 1545 (996-3146) nmol/L [median (25(th)-75(th) quartiles)] vs. 738 (390-2527) nmol/L, P

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalLife Sciences
Volume65
Issue number10
DOIs
Publication statusPublished - Jul 30 1999

Fingerprint

Inosine
Adenosine
Coronary Artery Disease
Fluids
Heart Valve Diseases
Nucleosides
Pericardium
Surgery
Thoracic Surgery
Monolayers
Homeostasis
Blood
Molecular Weight
Molecular weight
High Pressure Liquid Chromatography
Pericardial Fluid

Keywords

  • Adenosine
  • Coronary artery disease
  • Human
  • Inosine
  • Pericardial fluid
  • Plasma
  • Valvular heart disease

ASJC Scopus subject areas

  • Pharmacology

Cite this

Enhanced accumulation of pericardial fluid adenosine and inosine in patients with coronary artery disease. / Fazekas, Levente; Horkay, F.; Kékesi, V.; Huszár, E.; Barát, E.; Fazekas, Réka; Szabó, Tamás; Juhász-Nagy, A.; Naszlady, Attila.

In: Life Sciences, Vol. 65, No. 10, 30.07.1999, p. 1005-1012.

Research output: Contribution to journalArticle

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AU - Barát, E.

AU - Fazekas, Réka

AU - Szabó, Tamás

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