Energy homeostasis regulatory peptides in hibernating grizzly bears

J. Gardi, O. Lynne Nelson, Charles T. Robbins, Éva Szentirmai, Levente Kapás, James M. Krueger

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Grizzly bears (Ursus arctos horribilis) are inactive for up to 6. months during hibernation. They undergo profound seasonal changes in food intake, body mass, and energy expenditure. The circa-annual regulation of metabolism is poorly understood. In this study, we measured plasma ghrelin, leptin, obestatin, and neuropeptide-Y (NPY) levels, hormones known to be involved in the regulation of energy homeostasis, in ten grizzly bears. Blood samples were collected during the active summer period, early hibernation and late hibernation. Plasma levels of leptin, obestatin, and NPY did not change between the active and the hibernation periods. Plasma total ghrelin and desacyl-ghrelin concentrations significantly decreased during the inactive winter period compared to summer levels. The elevated ghrelin levels may help enhance body mass during pre-hibernation, while the low plasma ghrelin concentrations during hibernation season may contribute to the maintenance of hypophagia, low energy utilization and behavioral inactivity. Our results suggest that ghrelin plays a potential role in the regulation of metabolic changes and energy homeostasis during hibernation in grizzly bears.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalGeneral and Comparative Endocrinology
Volume172
Issue number1
DOIs
Publication statusPublished - May 15 2011

Fingerprint

Ursidae
Hibernation
Ghrelin
Ursus arctos
ghrelin
hibernation
homeostasis
Homeostasis
peptides
Peptides
energy
neuropeptide Y
Neuropeptide Y
Leptin
leptin
undereating
summer
energy expenditure
Energy Metabolism
food intake

Keywords

  • Energy balance
  • Food intake
  • Ghrelin
  • Hibernation
  • Leptin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Gardi, J., Nelson, O. L., Robbins, C. T., Szentirmai, É., Kapás, L., & Krueger, J. M. (2011). Energy homeostasis regulatory peptides in hibernating grizzly bears. General and Comparative Endocrinology, 172(1), 181-183. https://doi.org/10.1016/j.ygcen.2010.12.015

Energy homeostasis regulatory peptides in hibernating grizzly bears. / Gardi, J.; Nelson, O. Lynne; Robbins, Charles T.; Szentirmai, Éva; Kapás, Levente; Krueger, James M.

In: General and Comparative Endocrinology, Vol. 172, No. 1, 15.05.2011, p. 181-183.

Research output: Contribution to journalArticle

Gardi, J, Nelson, OL, Robbins, CT, Szentirmai, É, Kapás, L & Krueger, JM 2011, 'Energy homeostasis regulatory peptides in hibernating grizzly bears', General and Comparative Endocrinology, vol. 172, no. 1, pp. 181-183. https://doi.org/10.1016/j.ygcen.2010.12.015
Gardi, J. ; Nelson, O. Lynne ; Robbins, Charles T. ; Szentirmai, Éva ; Kapás, Levente ; Krueger, James M. / Energy homeostasis regulatory peptides in hibernating grizzly bears. In: General and Comparative Endocrinology. 2011 ; Vol. 172, No. 1. pp. 181-183.
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