Inbred mouse strains show characteristic susceptibility to S. typhimurium infections. The sensitivity of the same strains to endotoxin is not parallel. While C3H/He J and C57Bl/6J mice were highly susceptible to infection they showed more resistance to purified endotoxin than A/J, a mouse strain relatively resistant to infection. These findings suggest that the death of mice during S. typhimurium infection is not due only to toxic effects of its lipopolysaccharide.
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Molecular Biology