Endotoxin-induced impairment of vasodepressor responses in the pithed rat

M. Oguz Guc, Gillian A. Gray, Brian L. Furman, J. Parratt

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effects of Eschericia coli endotoxin on vascular responsiveness were compared with those of sodium nitroprusside in pithed rats. Infusion of endotoxin (250 μg kg-1 h-1) produced a fall in mean arterial blood pressure (11mmHg) and impaired vasodepressor responses to cndothclin, 5-hydroxytryptamine, acetylcholinc, bradykinin, sodium nitroprusside and salbutamol. Prevention of endotoxin-induced hypotension with vasopressin infusion (0.64 i.u. kg-1 h-1 i.v.) restored responsivencss to bradykinin, tended to restore responsivcncss to endothelin and sodium nitroprusside but failed to restore responsiveness to acetylcholinc, 5-HT or salbutamol. Infusion of sodium nitroprusside at a rate (400 μg kg-1h-1) producing a similar fall in blood pressure to that produced by endotoxin markedly impaired vasodepressor responsiveness to 5-HT. However, this was fully restored when the hypotension was prevented by vasopressin infusion. Vasodepressor responsiveness to either acetylcholine or salbutamol was not impaired by sodium nitroprusside in vasopressin-infused rats. The impairment of vasodepressor rcsponsiveness by endotoxin is not due to endotoxin-induccd hypotension and does not fit clearly with an endotoxin-mediated impairment of endothelial function.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalEuropean Journal of Pharmacology
Volume204
Issue number1
DOIs
Publication statusPublished - Oct 29 1991

Fingerprint

Endotoxins
Nitroprusside
Albuterol
Vasopressins
Serotonin
Bradykinin
Hypotension
Arterial Pressure
Controlled Hypotension
Endothelins
Acetylcholine
Blood Vessels
Blood Pressure

Keywords

  • Endotoxin
  • Nitroprusside (sodium)
  • Vascular reactivity
  • Vasodilators

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Endotoxin-induced impairment of vasodepressor responses in the pithed rat. / Guc, M. Oguz; Gray, Gillian A.; Furman, Brian L.; Parratt, J.

In: European Journal of Pharmacology, Vol. 204, No. 1, 29.10.1991, p. 63-70.

Research output: Contribution to journalArticle

Guc, M. Oguz ; Gray, Gillian A. ; Furman, Brian L. ; Parratt, J. / Endotoxin-induced impairment of vasodepressor responses in the pithed rat. In: European Journal of Pharmacology. 1991 ; Vol. 204, No. 1. pp. 63-70.
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