Endotoxin-induced impairment of vascular reactivity in the pithed rat

Role of arachidonic acid metabolites

G. A. Gray, B. L. Furman, J. Parratt

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effect of endotoxin on vascular reactivity was studied in pithed rats. Endotoxin infusion (1 mg kg -1h-1) impaired pressor responses to noradrenaline, angiotensin II, BAY K 8644, and stimulation of the spinal sympathetic outflow. The loss of reactivity was prevented by pretreatment with the cyclooxygenase inhibitor flurbiprofen or the dual cylcooxygenase/lipoxygenase inhibitor BW755C. The effect of endotoxin in impairing vascular reactivity to noradrenaline was mimicked by prostaglandin E2 and platelet-activating factor but not by the prostacyclin analogue iloprost. Platelet-activating factor also impaired responsiveness to sympathetic stimulation. These results suggest a role for cyclooxygenase products and, possibly, platelet-activating factor in endotoxin-induced impairment of vascular reactivity.

Original languageEnglish
Pages (from-to)395-406
Number of pages12
JournalCirculatory Shock
Volume31
Issue number4
Publication statusPublished - 1990

Fingerprint

Arachidonic Acid
Endotoxins
Blood Vessels
Platelet Activating Factor
Norepinephrine
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
Flurbiprofen
Iloprost
Lipoxygenase Inhibitors
Cyclooxygenase Inhibitors
Epoprostenol
Prostaglandin-Endoperoxide Synthases
Dinoprostone
Angiotensin II

Keywords

  • angiotensin II
  • BAY K 8644
  • endotoxin
  • iloprost
  • noradrenaline
  • platelet-activating factor
  • prostaglandin E

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Endotoxin-induced impairment of vascular reactivity in the pithed rat : Role of arachidonic acid metabolites. / Gray, G. A.; Furman, B. L.; Parratt, J.

In: Circulatory Shock, Vol. 31, No. 4, 1990, p. 395-406.

Research output: Contribution to journalArticle

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