Endotoxin impairs the response of rat anococcygeus muscle to electrical field stimulatin

M. Oguz Guc, Brian L. Furman, J. Parratt

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rat anococcygeus muscles were isolated 4 h after treatment with either E. coli endotoxin (20 mg kg-1 i.p.) or saline. The contractile responses of the muscle to electrical field stimulation, and to the α1-adrenoceptor agonist cirazoline were impaired by endotoxin treatment. Inhibition of the L-arginine pathway with L-NGnitro arginine methylester (3 × 10-5 M) failed to restore responsiveness to either electrical field stimulation or to cirazoline. Endotoxin impaired inhibitory responses to electrical field stimulation in preparations precontracted with cirazoline. Responsiveness to sodium nitroprusside was also impaired by endotoxin under these conditions. These results show an impairment by endotoxin of both contractile and inhibitory responses of the rat anococcygeus muscle to elecirical field stimulation. The impairment appears to be post-junctional. In contrast to the findings in vascular smooth muscle, the endotoxin-induced impairment of contractile responses does not appear to involve the L-arginine pathway.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalEuropean Journal of Pharmacology
Volume202
Issue number3
DOIs
Publication statusPublished - Sep 24 1991

Fingerprint

Endotoxins
Muscles
Electric Stimulation
Arginine
Nitroprusside
Vascular Smooth Muscle
Adrenergic Receptors
Escherichia coli
cirazoline

Keywords

  • (Electrical field stimulation)
  • Anococcygeus muscle (rat)
  • Endotoxin
  • L-Arginine pathway

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Endotoxin impairs the response of rat anococcygeus muscle to electrical field stimulatin. / Guc, M. Oguz; Furman, Brian L.; Parratt, J.

In: European Journal of Pharmacology, Vol. 202, No. 3, 24.09.1991, p. 397-401.

Research output: Contribution to journalArticle

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