Endotoxin fever in para-chlorophenylalanine (PCPA) treated newborn guinea pigs and kittens

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5 Citations (Scopus)

Abstract

Guinea pigs aged 0-3 days responded to 0.2 μg icv. E. coli endotoxin with phasic changes in body temperature; two rises separated by a marked fall. This fall was diminished in PCPA treated animals. In 5-10 day-old kittens the otherwise monophasic endotoxin fever was modified by PCPA treatment; the rise was attenuated in the period corresponding to the transient temperature fall of guinea pigs.

Original languageEnglish
Pages (from-to)1585-1588
Number of pages4
JournalLife Sciences
Volume22
Issue number18
DOIs
Publication statusPublished - May 8 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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