Guinea pigs aged 0-3 days responded to 0.2 μg icv. E. coli endotoxin with phasic changes in body temperature; two rises separated by a marked fall. This fall was diminished in PCPA treated animals. In 5-10 day-old kittens the otherwise monophasic endotoxin fever was modified by PCPA treatment; the rise was attenuated in the period corresponding to the transient temperature fall of guinea pigs.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)