Endothelium removal does not affect potentiation by neuropeptide Y in rabbit ear artery

D. Budai, Hai Quoc Vu, Sue Piper Dickles

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Influence of endothelial cells on the effect of neuropeptide Y (NPY) was investigated. NPY (30 nM) doubled the vasoconstriction elicited by transmural nerve stimulation (8 pulses at 8 Hz) in the perfused rabbit ear artery with or without endothelium. Conditions that increase the biophase concentration of norepinephrine, longer stimulation trains or application of yohimbine, decreased the potentiation by NPY, although in the presence of cocaine potentiation by NPY was unchanged. However, no significant differences between control and endothelium-removed arteries were revealed. Thus modulation of adrenergic neurotransmission by NPY does not depend on endothelium-derived vasoactive substances.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalEuropean Journal of Pharmacology
Volume168
Issue number1
DOIs
Publication statusPublished - Sep 1 1989

Fingerprint

Neuropeptide Y
Endothelium
Ear
Arteries
Rabbits
Yohimbine
Vasoconstriction
Cocaine
Synaptic Transmission
Adrenergic Agents
Norepinephrine
Endothelial Cells

Keywords

  • (Rabbit)
  • Adrenergic nerve stimulation
  • Ear artery
  • Endothelium
  • Neuropeptide Y

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Endothelium removal does not affect potentiation by neuropeptide Y in rabbit ear artery. / Budai, D.; Vu, Hai Quoc; Dickles, Sue Piper.

In: European Journal of Pharmacology, Vol. 168, No. 1, 01.09.1989, p. 97-100.

Research output: Contribution to journalArticle

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