Endothelin release by capsaicin in isolated working rat heart

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Abstract

Capsaicin (1 nM-1 μM) induced a concentration-dependent decrease in heart rate, coronary flow, aortic flow, left ventricular developed pressure and its first derivative, dP/dt(max) in isolated working rat heart. The effect of 10 nM capsaicin was mimicked by 0.1 nM endothelin. PD142893 (200 nM), a non-selective endothelin receptor blocking agent antagonized the effect of either endothelin (0.1 nM) or capsaicin (10 nM). We conclude that the majority of the effects of capsaicin in the rat heart are mediated by neural endothelin release. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalEuropean Journal of Pharmacology
Volume376
Issue number3
DOIs
Publication statusPublished - Jul 9 1999

Keywords

  • Capsaicin
  • Endothelin
  • Heart, isolated, working

ASJC Scopus subject areas

  • Pharmacology

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