Endothelin receptors, second messengers, and actions in bone

P. H. Stern, A. Tatrai, D. E. Semler, Kyeong Lee Suk Kyeong Lee, P. Lakatos, P. J. Strieleman, G. Tarjan, J. L. Sanders

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Endothelins are a class of peptides that are produced by and elicit responses in many tissues. A growing literature documents the presence and effects of endothelins in bone. Both endothelin(A) and endothelin(B) receptors have been demonstrated in osteoblastic cells by ligand binding. Major signal transduction pathways for endothelin in bone cells appear to be stimulation of phospholipid turnover, by activation of A, C and D phospholipases, stimulation of calcium flux from intracellular and extracellular stores and activation of tyrosine kinases. Endothelins also modulate calcium signaling elicited by other agents in osteoblastic cells. The parathyroid hormone-stimulated calcium transient in GMR-106 cells is enhanced by endothelins, acting through an endothelin(B) receptor, whereas the parathyroid hormone-stimulated increase in cyclic AMP is inhibited by endothelins. Phenotypic responses to endothelin-1 include changes in alkaline phosphatase activity, stimulation of osteocalcin and osteopontin message, stimulation of collagen and noncollagenous protein synthesis, inhibition of osteoclast motility and stimulation of prostaglandin-dependent resorption. Endothelin-1 also enhances the interleukin-1-induced increase in interleukin- 6. Endothelins can also potentially affect calcium metabolism through their actions to inhibit the secretion of parathyroid hormone.

Original languageEnglish
JournalJournal of Nutrition
Volume125
Issue number7 SUPPL.
Publication statusPublished - 1995

Fingerprint

Endothelin Receptors
endothelins
second messengers
Endothelins
Second Messenger Systems
bones
Bone and Bones
receptors
Parathyroid Hormone
Endothelin B Receptors
Endothelin-1
Calcium
parathyroid hormone
calcium
Phospholipase D
Osteopontin
Calcium Signaling
Osteocalcin
Type C Phospholipases
Osteoclasts

Keywords

  • bone
  • endothelin
  • mouse
  • osteoblast
  • rat

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Stern, P. H., Tatrai, A., Semler, D. E., Suk Kyeong Lee, K. L., Lakatos, P., Strieleman, P. J., ... Sanders, J. L. (1995). Endothelin receptors, second messengers, and actions in bone. Journal of Nutrition, 125(7 SUPPL.).

Endothelin receptors, second messengers, and actions in bone. / Stern, P. H.; Tatrai, A.; Semler, D. E.; Suk Kyeong Lee, Kyeong Lee; Lakatos, P.; Strieleman, P. J.; Tarjan, G.; Sanders, J. L.

In: Journal of Nutrition, Vol. 125, No. 7 SUPPL., 1995.

Research output: Contribution to journalArticle

Stern, PH, Tatrai, A, Semler, DE, Suk Kyeong Lee, KL, Lakatos, P, Strieleman, PJ, Tarjan, G & Sanders, JL 1995, 'Endothelin receptors, second messengers, and actions in bone', Journal of Nutrition, vol. 125, no. 7 SUPPL..
Stern PH, Tatrai A, Semler DE, Suk Kyeong Lee KL, Lakatos P, Strieleman PJ et al. Endothelin receptors, second messengers, and actions in bone. Journal of Nutrition. 1995;125(7 SUPPL.).
Stern, P. H. ; Tatrai, A. ; Semler, D. E. ; Suk Kyeong Lee, Kyeong Lee ; Lakatos, P. ; Strieleman, P. J. ; Tarjan, G. ; Sanders, J. L. / Endothelin receptors, second messengers, and actions in bone. In: Journal of Nutrition. 1995 ; Vol. 125, No. 7 SUPPL.
@article{01f8cc7322944b2f93be546d9129178c,
title = "Endothelin receptors, second messengers, and actions in bone",
abstract = "Endothelins are a class of peptides that are produced by and elicit responses in many tissues. A growing literature documents the presence and effects of endothelins in bone. Both endothelin(A) and endothelin(B) receptors have been demonstrated in osteoblastic cells by ligand binding. Major signal transduction pathways for endothelin in bone cells appear to be stimulation of phospholipid turnover, by activation of A, C and D phospholipases, stimulation of calcium flux from intracellular and extracellular stores and activation of tyrosine kinases. Endothelins also modulate calcium signaling elicited by other agents in osteoblastic cells. The parathyroid hormone-stimulated calcium transient in GMR-106 cells is enhanced by endothelins, acting through an endothelin(B) receptor, whereas the parathyroid hormone-stimulated increase in cyclic AMP is inhibited by endothelins. Phenotypic responses to endothelin-1 include changes in alkaline phosphatase activity, stimulation of osteocalcin and osteopontin message, stimulation of collagen and noncollagenous protein synthesis, inhibition of osteoclast motility and stimulation of prostaglandin-dependent resorption. Endothelin-1 also enhances the interleukin-1-induced increase in interleukin- 6. Endothelins can also potentially affect calcium metabolism through their actions to inhibit the secretion of parathyroid hormone.",
keywords = "bone, endothelin, mouse, osteoblast, rat",
author = "Stern, {P. H.} and A. Tatrai and Semler, {D. E.} and {Suk Kyeong Lee}, {Kyeong Lee} and P. Lakatos and Strieleman, {P. J.} and G. Tarjan and Sanders, {J. L.}",
year = "1995",
language = "English",
volume = "125",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "7 SUPPL.",

}

TY - JOUR

T1 - Endothelin receptors, second messengers, and actions in bone

AU - Stern, P. H.

AU - Tatrai, A.

AU - Semler, D. E.

AU - Suk Kyeong Lee, Kyeong Lee

AU - Lakatos, P.

AU - Strieleman, P. J.

AU - Tarjan, G.

AU - Sanders, J. L.

PY - 1995

Y1 - 1995

N2 - Endothelins are a class of peptides that are produced by and elicit responses in many tissues. A growing literature documents the presence and effects of endothelins in bone. Both endothelin(A) and endothelin(B) receptors have been demonstrated in osteoblastic cells by ligand binding. Major signal transduction pathways for endothelin in bone cells appear to be stimulation of phospholipid turnover, by activation of A, C and D phospholipases, stimulation of calcium flux from intracellular and extracellular stores and activation of tyrosine kinases. Endothelins also modulate calcium signaling elicited by other agents in osteoblastic cells. The parathyroid hormone-stimulated calcium transient in GMR-106 cells is enhanced by endothelins, acting through an endothelin(B) receptor, whereas the parathyroid hormone-stimulated increase in cyclic AMP is inhibited by endothelins. Phenotypic responses to endothelin-1 include changes in alkaline phosphatase activity, stimulation of osteocalcin and osteopontin message, stimulation of collagen and noncollagenous protein synthesis, inhibition of osteoclast motility and stimulation of prostaglandin-dependent resorption. Endothelin-1 also enhances the interleukin-1-induced increase in interleukin- 6. Endothelins can also potentially affect calcium metabolism through their actions to inhibit the secretion of parathyroid hormone.

AB - Endothelins are a class of peptides that are produced by and elicit responses in many tissues. A growing literature documents the presence and effects of endothelins in bone. Both endothelin(A) and endothelin(B) receptors have been demonstrated in osteoblastic cells by ligand binding. Major signal transduction pathways for endothelin in bone cells appear to be stimulation of phospholipid turnover, by activation of A, C and D phospholipases, stimulation of calcium flux from intracellular and extracellular stores and activation of tyrosine kinases. Endothelins also modulate calcium signaling elicited by other agents in osteoblastic cells. The parathyroid hormone-stimulated calcium transient in GMR-106 cells is enhanced by endothelins, acting through an endothelin(B) receptor, whereas the parathyroid hormone-stimulated increase in cyclic AMP is inhibited by endothelins. Phenotypic responses to endothelin-1 include changes in alkaline phosphatase activity, stimulation of osteocalcin and osteopontin message, stimulation of collagen and noncollagenous protein synthesis, inhibition of osteoclast motility and stimulation of prostaglandin-dependent resorption. Endothelin-1 also enhances the interleukin-1-induced increase in interleukin- 6. Endothelins can also potentially affect calcium metabolism through their actions to inhibit the secretion of parathyroid hormone.

KW - bone

KW - endothelin

KW - mouse

KW - osteoblast

KW - rat

UR - http://www.scopus.com/inward/record.url?scp=0029062546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029062546&partnerID=8YFLogxK

M3 - Article

VL - 125

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 7 SUPPL.

ER -