Endothelin ETA and ETB receptor expression in the human trigeminal ganglion

Rolf Uddman, J. Tajti, Lars Olaf Cardell, Frank Sundler, Erik Uddman, Lars Edvinsson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Endothelin is a potent peptide mediator that is synthesized by a number of cells. Previous studies have revealed the occurrence of endothelin in nerve cell bodies of some peripheral ganglia. Endothelin mediates its effects via two distinct receptor subtypes ETA and ETB. The present study was designed to investigate the presence of these two receptors in the human trigeminal ganglion. Methods: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to show the presence of mRNA encoding ETA and ETB receptors in the human trigeminal ganglion. To localize the protein immunocytochemistry with antibodies against the endothelin receptors was used. Results: Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed mRNA for both receptor subtypes in the human trigeminal ganglion. Immunocytochemistry revealed numerous cell bodies containing the ETA and the ETB receptor proteins. Conclusions: The expression of ETA and ETB receptors in the human trigeminal ganglion suggests a role for endothelin in autonomic and sensory neural transmission.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalNeuroendocrinology Letters
Volume27
Issue number3
Publication statusPublished - Jun 2006

Fingerprint

Trigeminal Ganglion
Endothelins
Reverse Transcriptase Polymerase Chain Reaction
Immunohistochemistry
Endothelin Receptors
Messenger RNA
Synaptic Transmission
Ganglia
Proteins
Cell Count
Neurons
Peptides
Antibodies
Cell Body

Keywords

  • Endothelin receptors
  • Sensory transmission
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Uddman, R., Tajti, J., Cardell, L. O., Sundler, F., Uddman, E., & Edvinsson, L. (2006). Endothelin ETA and ETB receptor expression in the human trigeminal ganglion. Neuroendocrinology Letters, 27(3), 345-349.

Endothelin ETA and ETB receptor expression in the human trigeminal ganglion. / Uddman, Rolf; Tajti, J.; Cardell, Lars Olaf; Sundler, Frank; Uddman, Erik; Edvinsson, Lars.

In: Neuroendocrinology Letters, Vol. 27, No. 3, 06.2006, p. 345-349.

Research output: Contribution to journalArticle

Uddman, R, Tajti, J, Cardell, LO, Sundler, F, Uddman, E & Edvinsson, L 2006, 'Endothelin ETA and ETB receptor expression in the human trigeminal ganglion', Neuroendocrinology Letters, vol. 27, no. 3, pp. 345-349.
Uddman R, Tajti J, Cardell LO, Sundler F, Uddman E, Edvinsson L. Endothelin ETA and ETB receptor expression in the human trigeminal ganglion. Neuroendocrinology Letters. 2006 Jun;27(3):345-349.
Uddman, Rolf ; Tajti, J. ; Cardell, Lars Olaf ; Sundler, Frank ; Uddman, Erik ; Edvinsson, Lars. / Endothelin ETA and ETB receptor expression in the human trigeminal ganglion. In: Neuroendocrinology Letters. 2006 ; Vol. 27, No. 3. pp. 345-349.
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