Endothelin ETA and ETB receptor expression in the human trigeminal ganglion

Rolf Uddman, Janos Tajti, Lars Olaf Cardell, Frank Sundler, Erik Uddman, Lars Edvinsson

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15 Citations (Scopus)

Abstract

Objectives: Endothelin is a potent peptide mediator that is synthesized by a number of cells. Previous studies have revealed the occurrence of endothelin in nerve cell bodies of some peripheral ganglia. Endothelin mediates its effects via two distinct receptor subtypes ETA and ETB. The present study was designed to investigate the presence of these two receptors in the human trigeminal ganglion. Methods: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to show the presence of mRNA encoding ETA and ETB receptors in the human trigeminal ganglion. To localize the protein immunocytochemistry with antibodies against the endothelin receptors was used. Results: Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed mRNA for both receptor subtypes in the human trigeminal ganglion. Immunocytochemistry revealed numerous cell bodies containing the ETA and the ETB receptor proteins. Conclusions: The expression of ETA and ETB receptors in the human trigeminal ganglion suggests a role for endothelin in autonomic and sensory neural transmission.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalNeuroendocrinology Letters
Volume27
Issue number3
Publication statusPublished - Jun 1 2006

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Keywords

  • Endothelin receptors
  • Sensory transmission
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Uddman, R., Tajti, J., Cardell, L. O., Sundler, F., Uddman, E., & Edvinsson, L. (2006). Endothelin ETA and ETB receptor expression in the human trigeminal ganglion. Neuroendocrinology Letters, 27(3), 345-349.