Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease

Holger Bohnemeier, Yigal M. Pinto, F. Horkay, Miklós Tóth, A. Juhász-Nagy, Hans Dieter Orzechowski, Michael Böhm, Martin Paul

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Endothelin-1 converting-enzyme (ECE-1) cleaves the precursor, big- endothelin-1 to the active peptide endothelin-1. The aim of this study was to investigate whether ECE-1 mRNA expression is modified in human cardiovascular disease. Tissue samples from the left human atrium were analyzed for ECE-1 expression and related to different clinical parameters. A quantitative PCR assay (qPCR) with competitive and non-competitive standards was established. The ECE-1 measurements were normalized by a GAPDH qPCR. Patients who suffered from a myocardial infarction had elevated ECE-1 levels when compared to controls (5.81 ± 0.76 vs. 3.20 ± 0.51 fg ECE-1, ng GAPDH, p

Original languageEnglish
Pages (from-to)417-437
Number of pages21
JournalClinical and Experimental Hypertension
Volume20
Issue number4
Publication statusPublished - May 1998

Fingerprint

Endothelin-1
Cardiovascular Diseases
Polymerase Chain Reaction
Messenger RNA
Heart Atria
Myocardial Infarction
Peptides
Endothelin-Converting Enzymes

Keywords

  • Cardiovascular
  • Endothelin converting-enzyme
  • Human atrium
  • mRNA expression
  • qPCR

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Bohnemeier, H., Pinto, Y. M., Horkay, F., Tóth, M., Juhász-Nagy, A., Orzechowski, H. D., ... Paul, M. (1998). Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease. Clinical and Experimental Hypertension, 20(4), 417-437.

Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease. / Bohnemeier, Holger; Pinto, Yigal M.; Horkay, F.; Tóth, Miklós; Juhász-Nagy, A.; Orzechowski, Hans Dieter; Böhm, Michael; Paul, Martin.

In: Clinical and Experimental Hypertension, Vol. 20, No. 4, 05.1998, p. 417-437.

Research output: Contribution to journalArticle

Bohnemeier, H, Pinto, YM, Horkay, F, Tóth, M, Juhász-Nagy, A, Orzechowski, HD, Böhm, M & Paul, M 1998, 'Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease', Clinical and Experimental Hypertension, vol. 20, no. 4, pp. 417-437.
Bohnemeier, Holger ; Pinto, Yigal M. ; Horkay, F. ; Tóth, Miklós ; Juhász-Nagy, A. ; Orzechowski, Hans Dieter ; Böhm, Michael ; Paul, Martin. / Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease. In: Clinical and Experimental Hypertension. 1998 ; Vol. 20, No. 4. pp. 417-437.
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