Az endothelin-1 és szerepe diabetes mellitusban.

Translated title of the contribution: Endothelin-1 and its role in diabetes mellitus

B. Sármán, M. Tóth, A. Somogyi

Research output: Contribution to journalReview article


Endothelin-1 is mainly synthesised by the vascular endothelial cells and acts on the vascular smooth muscle. There are special endothelin receptors, endothelin receptor-A and endothelin receptor-B expressed on the vascular smooth muscle cells. Endothelin-1 through second messengers mobilises the intracellular calcium storage. The level of endothein-1 was found to be higher than normal in several diseases. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. The most severe and most frequent complications of diabetes mellitus are micro- and macroangiopathy. The authors summarise the physiological functions of endothelin-1 and its role in the development of diabetic angiopathy.

Original languageHungarian
Pages (from-to)2877-2881
Number of pages5
JournalOrvosi hetilap
Issue number45
Publication statusPublished - Nov 9 1997


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sármán, B., Tóth, M., & Somogyi, A. (1997). Az endothelin-1 és szerepe diabetes mellitusban. Orvosi hetilap, 138(45), 2877-2881.