Endothelial nitric oxide synthase is up-regulated in the umbilical cord in pregnancies complicated with intrauterine growth retardation

Zsuzsanna Hracsko, E. Hermesz, Agnes Ferencz, H. Orvos, Zoltan Novak, A. Pál, I. Varga

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: NO and NO synthases (NOS) play an important role in the physiology of the fetomaternal blood circulation, although their expression in pathological conditions is unclear. Intrauterine growth retardation (IUGR) is a disorder most probably caused by abnormality of the fetomaternal bloodflow. Materials and Methods: The expression of endothelial NOS (ecNOS) from arteria umbilicalis and the nitrite and peroxynitrite level of umbilical blood were determined. Major consequences of peroxynitrite toxicity are lipid peroxidation and glutathione depletion; these parameters were also measured. Finally, superoxide dismutase (SOD) activity was assayed to evaluate the level of superoxide anions. Results: Elevated expression of ecNOS was found to be coupled with significantly lower SOD activity and glutathione level, and increased lipid peroxidation in IUGR neonates. Conclusion: The increased NO indices could represent a compensatory effort to improve placental bloodflow, but in IUGR neonates it is coupled with inadequate antioxidant defence, resulting in significant oxidative stress.

Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalIn Vivo
Volume23
Issue number5
Publication statusPublished - Sep 2009

Fingerprint

Fetal Growth Retardation
Nitric Oxide Synthase Type III
Umbilical Cord
Peroxynitrous Acid
Nitric Oxide Synthase
Pregnancy
Lipid Peroxidation
Superoxide Dismutase
Glutathione
Lipids
Umbilicus
Oxidative stress
Blood Circulation
Physiology
Hemodynamics
Nitrites
Superoxides
Toxicity
Oxidative Stress
Blood

Keywords

  • IUGR
  • Nitrogen oxide
  • Oxidative stress
  • Umbilical cord

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Endothelial nitric oxide synthase is up-regulated in the umbilical cord in pregnancies complicated with intrauterine growth retardation. / Hracsko, Zsuzsanna; Hermesz, E.; Ferencz, Agnes; Orvos, H.; Novak, Zoltan; Pál, A.; Varga, I.

In: In Vivo, Vol. 23, No. 5, 09.2009, p. 727-732.

Research output: Contribution to journalArticle

@article{5d6d10fa0b0c45238e1611a1037311a8,
title = "Endothelial nitric oxide synthase is up-regulated in the umbilical cord in pregnancies complicated with intrauterine growth retardation",
abstract = "Background: NO and NO synthases (NOS) play an important role in the physiology of the fetomaternal blood circulation, although their expression in pathological conditions is unclear. Intrauterine growth retardation (IUGR) is a disorder most probably caused by abnormality of the fetomaternal bloodflow. Materials and Methods: The expression of endothelial NOS (ecNOS) from arteria umbilicalis and the nitrite and peroxynitrite level of umbilical blood were determined. Major consequences of peroxynitrite toxicity are lipid peroxidation and glutathione depletion; these parameters were also measured. Finally, superoxide dismutase (SOD) activity was assayed to evaluate the level of superoxide anions. Results: Elevated expression of ecNOS was found to be coupled with significantly lower SOD activity and glutathione level, and increased lipid peroxidation in IUGR neonates. Conclusion: The increased NO indices could represent a compensatory effort to improve placental bloodflow, but in IUGR neonates it is coupled with inadequate antioxidant defence, resulting in significant oxidative stress.",
keywords = "IUGR, Nitrogen oxide, Oxidative stress, Umbilical cord",
author = "Zsuzsanna Hracsko and E. Hermesz and Agnes Ferencz and H. Orvos and Zoltan Novak and A. P{\'a}l and I. Varga",
year = "2009",
month = "9",
language = "English",
volume = "23",
pages = "727--732",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "5",

}

TY - JOUR

T1 - Endothelial nitric oxide synthase is up-regulated in the umbilical cord in pregnancies complicated with intrauterine growth retardation

AU - Hracsko, Zsuzsanna

AU - Hermesz, E.

AU - Ferencz, Agnes

AU - Orvos, H.

AU - Novak, Zoltan

AU - Pál, A.

AU - Varga, I.

PY - 2009/9

Y1 - 2009/9

N2 - Background: NO and NO synthases (NOS) play an important role in the physiology of the fetomaternal blood circulation, although their expression in pathological conditions is unclear. Intrauterine growth retardation (IUGR) is a disorder most probably caused by abnormality of the fetomaternal bloodflow. Materials and Methods: The expression of endothelial NOS (ecNOS) from arteria umbilicalis and the nitrite and peroxynitrite level of umbilical blood were determined. Major consequences of peroxynitrite toxicity are lipid peroxidation and glutathione depletion; these parameters were also measured. Finally, superoxide dismutase (SOD) activity was assayed to evaluate the level of superoxide anions. Results: Elevated expression of ecNOS was found to be coupled with significantly lower SOD activity and glutathione level, and increased lipid peroxidation in IUGR neonates. Conclusion: The increased NO indices could represent a compensatory effort to improve placental bloodflow, but in IUGR neonates it is coupled with inadequate antioxidant defence, resulting in significant oxidative stress.

AB - Background: NO and NO synthases (NOS) play an important role in the physiology of the fetomaternal blood circulation, although their expression in pathological conditions is unclear. Intrauterine growth retardation (IUGR) is a disorder most probably caused by abnormality of the fetomaternal bloodflow. Materials and Methods: The expression of endothelial NOS (ecNOS) from arteria umbilicalis and the nitrite and peroxynitrite level of umbilical blood were determined. Major consequences of peroxynitrite toxicity are lipid peroxidation and glutathione depletion; these parameters were also measured. Finally, superoxide dismutase (SOD) activity was assayed to evaluate the level of superoxide anions. Results: Elevated expression of ecNOS was found to be coupled with significantly lower SOD activity and glutathione level, and increased lipid peroxidation in IUGR neonates. Conclusion: The increased NO indices could represent a compensatory effort to improve placental bloodflow, but in IUGR neonates it is coupled with inadequate antioxidant defence, resulting in significant oxidative stress.

KW - IUGR

KW - Nitrogen oxide

KW - Oxidative stress

KW - Umbilical cord

UR - http://www.scopus.com/inward/record.url?scp=70350074582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350074582&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 727

EP - 732

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 5

ER -