Endothelial nitric oxide synthase is up-regulated in the umbilical cord in pregnancies complicated with intrauterine growth retardation

Zsuzsanna Hracsko, Edit Hermesz, Agnes Ferencz, Hajnalka Orvos, Zoltan Novak, Attila Pal, Ilona Szollosi Varga

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: NO and NO synthases (NOS) play an important role in the physiology of the fetomaternal blood circulation, although their expression in pathological conditions is unclear. Intrauterine growth retardation (IUGR) is a disorder most probably caused by abnormality of the fetomaternal bloodflow. Materials and Methods: The expression of endothelial NOS (ecNOS) from arteria umbilicalis and the nitrite and peroxynitrite level of umbilical blood were determined. Major consequences of peroxynitrite toxicity are lipid peroxidation and glutathione depletion; these parameters were also measured. Finally, superoxide dismutase (SOD) activity was assayed to evaluate the level of superoxide anions. Results: Elevated expression of ecNOS was found to be coupled with significantly lower SOD activity and glutathione level, and increased lipid peroxidation in IUGR neonates. Conclusion: The increased NO indices could represent a compensatory effort to improve placental bloodflow, but in IUGR neonates it is coupled with inadequate antioxidant defence, resulting in significant oxidative stress.

Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalIn Vivo
Volume23
Issue number5
Publication statusPublished - Sep 1 2009

Keywords

  • IUGR
  • Nitrogen oxide
  • Oxidative stress
  • Umbilical cord

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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