Endothelial cells in inflammation and angiogenesis

Zoltán Szekanecz, Alisa E. Koch

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Endothelial cells are involved in leukocyte extravasation underlying inflammation. A number of adhesion molecules play a role in leukocyte-endothelial interactions. New vessel formation, termed angiogenesis, is also crucial for leukocyte extravasation. The outcome of neovascularization is highly dependent on the balance or imbalance between angiogenic mediators and inhibitors. There have been several attempts to therapeutically interfere with the cellular and molecular mechanisms, such as leukocyte-endothelial cell adhesion and angiogenesis. Most studies have been performed using animal models of various types of inflammation, such as arthritis. In addition, a very limited number of human clinical trials gave promising results. In this review, authors summarize the most relevant information on adhesion molecules, as well as angiogenic and angiostatic agents. In addition, further perspectives of anti-adhesive and anti-angiogenic therapy are also discussed. Specific targeting of pathological endothelial function including adhesion and angiogenesis, may be useful for the future management of various inflammatory diseases.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalCurrent Drug Targets: Inflammation and Allergy
Volume4
Issue number3
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Angiogenesis
  • Endothelial cells
  • Inflammation
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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