Endoscopic versus Laparoscopic Full-Thickness Biopsy in the Pathological Evaluation of the Enteric Nervous System

Bodil Ohlsson, Rita J. Gustafsson, Ervin Toth, Bèla Veress, Henrik Thorlacius

Research output: Contribution to journalArticle

Abstract

A full-thickness biopsy of the bowel wall is required to evaluate the enteric nervous system. A patient with aggravating gastrointestinal symptoms underwent a laparoscopic full-thickness biopsy of the ileum and, 1 year later, an endoscopic full-thickness biopsy of the sigmoid colon. Both samples showed enteric neuropathy characterized by vacuolated and enlarged neurons. The length of the myenteric plexus was greater in the endoscopic (23 mm) compared to the laparoscopic (11 mm) biopsy, with fewer tissue artefacts in the laparoscopic approach. Clinical deterioration was paralleled by enteric neuropathy with an increase in the percentage of vacuolated and enlarged enteric neurons from 24 to 35%.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalCase Reports in Gastroenterology
Volume12
Issue number1
DOIs
Publication statusPublished - Apr 13 2018

Keywords

  • Enteric dysmotility
  • Enteric neuropathy
  • Full-thickness biopsy
  • Gastrointestinal symptoms

ASJC Scopus subject areas

  • Gastroenterology

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