Endoscopic diagnosis of cytomegalovirus infection of upper gastrointestinal tract in solid organ transplant recipients: Hungarian single-center experience

Antal Péter, Gábor Telkes, Marina Varga, Eniko Sárváry, Ilona Kovalszky

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Cytomegalovirus (CMV) is considered to be the major cause of upper gastrointestinal (GI) symptoms in organ transplant recipients. In the diagnosis of GI CMV infection the detection of the virus in the mucosa is essential. The aim of the study was to evaluate the significance of CMV, detected in biopsy specimens from stomach and duodenum of solid organ transplant recipients. Methods: Data of 227 elective upper endoscopies on symptomatic organ transplant recipients were evaluated for clinical symptoms, endoscopic changes and conventional histologic alterations of mucosal biopsy samples. Qualitative PCR was performed for detection of the presence of CMV-DNA in each biopsy materials. Results: CMV-DNA was detected in biopsy samples of 91 patients (40.1%) while only in 20 cases (8.8%) the signs of CMV infections were found by conventional histology (p < 0.00001). No considerable differences could be observed in symptomatic, histologic alterations between CMV-PCR positive and negative groups. There were no endoscopic changes in 25.3% of CMV-PCR positive and 5.1% of negative patients. Conclusions: Qualitative PCR is an accurate method for the detection of CMV in the mucosa of the GI tract. Further investigations are needed for determination of the exact pathological role of detected CMV.

Original languageEnglish
Pages (from-to)580-584
Number of pages5
JournalClinical Transplantation
Volume18
Issue number5
DOIs
Publication statusPublished - Oct 1 2004

Keywords

  • Cytomegalovirus
  • Endoscopic diagnosis
  • Gastrointestinal
  • Histology
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Transplantation

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