Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis

Eugene J. Kucharz, Sándor Szántó, Mariana Ivanova Goycheva, Milan Petronijević, Ksenija Šimnovec, Marcin Domżalski, Luca Gallelli, Zdravko Kamenov, Jerzy Konstantynowicz, Goran Radunović, Boris Šteňo, Rumen Stoilov, Rasto Stok, Radovan Vrana, Olivier Bruyère, Cyrus Cooper, Jean Yves Reginster

Research output: Contribution to journalReview article

3 Citations (Scopus)


Osteoarthritis (OA) is characterized by deterioration of the joints and associated with considerable pain and disability. OA is a chronic disease that requires intervention with both non-pharmacological and pharmacological treatment modalities and, inevitably, disease progression may necessitate successive treatments throughout the course of the disease. There is increasing data on the shortfalls of current pharmacological treatment of OA, and safety concerns associated with analgesic therapy use in OA arising from increasing evidence of gastrointestinal, cardiovascular, hepatic and renal adverse events with paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs). Consequently, symptomatic slow-acting drugs for OA (SYSADOAs) may now be considered as a first-line treatment for knee OA, with a particular emphasis placed on the outstanding benefit: risk ratio of pharmaceutical-grade glucosamine and chondroitin sulfate formulations. In this short communication we review recent publications concerned with the safety of paracetamol, NSAIDs and SYSADOAs. Greater understanding of the benefits and limitations of current medications will lead to better disease management in OA. Furthermore, adherence to guideline recommendations across Europe and internationally, such as those from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), will promote evidence-based medicine and patient-centric care, ultimately leading to greater physician and patient satisfaction.

Original languageEnglish
Pages (from-to)1117-1123
Number of pages7
JournalRheumatology International
Issue number7
Publication statusPublished - Jul 1 2019


  • Osteoarthritis
  • Paracetamol
  • Safety

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis'. Together they form a unique fingerprint.

  • Cite this

    Kucharz, E. J., Szántó, S., Ivanova Goycheva, M., Petronijević, M., Šimnovec, K., Domżalski, M., Gallelli, L., Kamenov, Z., Konstantynowicz, J., Radunović, G., Šteňo, B., Stoilov, R., Stok, R., Vrana, R., Bruyère, O., Cooper, C., & Reginster, J. Y. (2019). Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis. Rheumatology International, 39(7), 1117-1123. https://doi.org/10.1007/s00296-019-04332-6