Endoplasmic reticulum stress

G. Bánhegyi, Peter Baumeister, Angelo Benedetti, Dezheng Dong, Yong Fu, Amy S. Lee, Jianze Li, Changhui Mao, E. Margittai, Min Ni, Wulf Paschen, Simona Piccirella, Silvia Senesi, Roberto Sitia, Miao Wang, Wei Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

94 Citations (Scopus)

Abstract

Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress-sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages58-71
Number of pages14
Volume1113
DOIs
Publication statusPublished - Oct 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1113
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Endoplasmic Reticulum Stress
Plasma Cells
Brain Ischemia
Endoplasmic Reticulum
Organelles
Type 2 Diabetes Mellitus
Insulin Resistance
Carcinogenesis
Biomarkers
Homeostasis
Medical problems
Obesity
Apoptosis
Machinery
Tumors
Insulin
Tissue
Plasmas
Neoplasms
Proteins

Keywords

  • Cerebral ischemia
  • Endoplasmic reticulum
  • Glucocorticoids
  • GRP78
  • Metabolic syndrome
  • Obesity
  • Plasma cell
  • Stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bánhegyi, G., Baumeister, P., Benedetti, A., Dong, D., Fu, Y., Lee, A. S., ... Yang, W. (2007). Endoplasmic reticulum stress. In Annals of the New York Academy of Sciences (Vol. 1113, pp. 58-71). (Annals of the New York Academy of Sciences; Vol. 1113). https://doi.org/10.1196/annals.1391.007

Endoplasmic reticulum stress. / Bánhegyi, G.; Baumeister, Peter; Benedetti, Angelo; Dong, Dezheng; Fu, Yong; Lee, Amy S.; Li, Jianze; Mao, Changhui; Margittai, E.; Ni, Min; Paschen, Wulf; Piccirella, Simona; Senesi, Silvia; Sitia, Roberto; Wang, Miao; Yang, Wei.

Annals of the New York Academy of Sciences. Vol. 1113 2007. p. 58-71 (Annals of the New York Academy of Sciences; Vol. 1113).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bánhegyi, G, Baumeister, P, Benedetti, A, Dong, D, Fu, Y, Lee, AS, Li, J, Mao, C, Margittai, E, Ni, M, Paschen, W, Piccirella, S, Senesi, S, Sitia, R, Wang, M & Yang, W 2007, Endoplasmic reticulum stress. in Annals of the New York Academy of Sciences. vol. 1113, Annals of the New York Academy of Sciences, vol. 1113, pp. 58-71. https://doi.org/10.1196/annals.1391.007
Bánhegyi G, Baumeister P, Benedetti A, Dong D, Fu Y, Lee AS et al. Endoplasmic reticulum stress. In Annals of the New York Academy of Sciences. Vol. 1113. 2007. p. 58-71. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1391.007
Bánhegyi, G. ; Baumeister, Peter ; Benedetti, Angelo ; Dong, Dezheng ; Fu, Yong ; Lee, Amy S. ; Li, Jianze ; Mao, Changhui ; Margittai, E. ; Ni, Min ; Paschen, Wulf ; Piccirella, Simona ; Senesi, Silvia ; Sitia, Roberto ; Wang, Miao ; Yang, Wei. / Endoplasmic reticulum stress. Annals of the New York Academy of Sciences. Vol. 1113 2007. pp. 58-71 (Annals of the New York Academy of Sciences).
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