Endoplasmic reticulum calcium pumps and cancer

Atousa Arbabian, Jean Philippe Brouland, Pascal Gélébart, T. Kovács, Régis Bobe, Jocelyne Enouf, Béla Papp

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Endoplasmic reticulum calcium homeostasis is involved in a multitude of signaling, as well as "house-keeping" functions that control cell growth, differentiation or apoptosis in every human/eukaryotic cell. Calcium is actively accumulated in the endoplasmic reticulum by Sarco/Endoplasmic Reticulum Calcium transport ATPases (SERCA enzymes). SERCA-dependent calcium transport is the only calcium uptake mechanism in this organelle, and therefore the regulation of SERCA function by the cell constitutes a key mechanism to adjust calcium homeostasis in the endoplasmic reticulum depending on the cell type and its state of differentiation. The direct pharmacological modulation of SERCA activity affects cell differentiation and survival. SERCA expression levels can undergo significant changes during cell differentiation or tumorigenesis, leading to modified endoplasmic reticulum calcium storage. In several cell types such as cells of hematopoietic origin or various epithelial cells, two SERCA genes (SERCA2 and SERCA3) are simultaneously expressed. Expression levels of SERCA3, a lower calcium affinity calcium pump are highly variable. In several cell systems SERCA3 expression is selectively induced during differentiation, whereas during tumorigenesis and blastic transformation SERCA3 expression is decreased. These observations point at the existence of a cross-talk, via the regulation of SERCA3 levels, between endoplasmic reticulum calcium homeostasis and the control of cell differentiation, and show that endoplasmic reticulum calcium homeostasis itself can undergo remodeling during differentiation. The investigation of the anomalies of endoplasmic reticulum differentiation in tumor and leukemia cells may be useful for a better understanding of the contribution of calcium signaling to the establishment of malignant phenotypes.

Original languageEnglish
Pages (from-to)139-149
Number of pages11
JournalBioFactors
Volume37
Issue number3
DOIs
Publication statusPublished - May 2011

Fingerprint

Endoplasmic Reticulum
Pumps
Calcium
Neoplasms
Cell Differentiation
Homeostasis
Carcinogenesis
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Calcium Signaling
Eukaryotic Cells
Organelles
Cell growth
Cell Survival
Leukemia
Epithelial Cells
Adenosine Triphosphatases
Tumors
Pharmacology
Apoptosis
Phenotype

Keywords

  • Calcium
  • Cancer
  • Differentiation
  • Endoplasmic reticulum
  • SERCA

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Arbabian, A., Brouland, J. P., Gélébart, P., Kovács, T., Bobe, R., Enouf, J., & Papp, B. (2011). Endoplasmic reticulum calcium pumps and cancer. BioFactors, 37(3), 139-149. https://doi.org/10.1002/biof.142

Endoplasmic reticulum calcium pumps and cancer. / Arbabian, Atousa; Brouland, Jean Philippe; Gélébart, Pascal; Kovács, T.; Bobe, Régis; Enouf, Jocelyne; Papp, Béla.

In: BioFactors, Vol. 37, No. 3, 05.2011, p. 139-149.

Research output: Contribution to journalArticle

Arbabian, A, Brouland, JP, Gélébart, P, Kovács, T, Bobe, R, Enouf, J & Papp, B 2011, 'Endoplasmic reticulum calcium pumps and cancer', BioFactors, vol. 37, no. 3, pp. 139-149. https://doi.org/10.1002/biof.142
Arbabian A, Brouland JP, Gélébart P, Kovács T, Bobe R, Enouf J et al. Endoplasmic reticulum calcium pumps and cancer. BioFactors. 2011 May;37(3):139-149. https://doi.org/10.1002/biof.142
Arbabian, Atousa ; Brouland, Jean Philippe ; Gélébart, Pascal ; Kovács, T. ; Bobe, Régis ; Enouf, Jocelyne ; Papp, Béla. / Endoplasmic reticulum calcium pumps and cancer. In: BioFactors. 2011 ; Vol. 37, No. 3. pp. 139-149.
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