Endoplasmic reticulum: A metabolic compartment

Miklós Csala, Gábor Bánhegyi, Angelo Benedetti

Research output: Contribution to journalShort survey

77 Citations (Scopus)

Abstract

Several biochemical reactions and processes of cell biology are compartmentalized in the endoplasmic reticulum (ER). The view that the ER membrane is basically a scaffold for ER proteins, which is permeable to small molecules, is inconsistent with recent findings. The luminal micro-environment is characteristically different from the cytosol; its protein and glutathione thiols are remarkably more oxidized, and it contains a separate pyridine nucleotide pool. The substrate specificity and activity of certain luminal enzymes are dependent on selective transport of possible substrates and co-factors from the cytosol. Abundant biochemical, pharmacological, clinical and genetic data indicate that the barrier function of the lipid bilayer and specific transport activities in the membrane make the ER a separate metabolic compartment.

Original languageEnglish
Pages (from-to)2160-2165
Number of pages6
JournalFEBS letters
Volume580
Issue number9
DOIs
Publication statusPublished - Apr 17 2006

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Keywords

  • Barrier
  • Compartment
  • Endoplasmic reticulum
  • Latency
  • Lumen
  • Membrane
  • Permeability
  • Specificity
  • Transport

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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