Endometriosis: Harmful survival of an ectopic tissue

Janos Garai, Valeria Molnar, Tamas Varga, Miklos Koppan, Attila Torok, Jozsef Bodis

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Endometriosis results from implantation of endometrial tissue outside the uterine cavity. Endometriosis might remain asymptomatic and discovered accidentally. However, it may cause symptoms, which include chronic pelvic pain, bleeding, infertility, and increases susceptibility to development of adenocarcinoma. The most prevailing hypothesis is that endometriosis results from implantation of endometrial tissue that gains access to peritoneal cavity by retrograde flow during menstruation. The factors contributing to the establishment and persistence of the endometriotic lesions (plaques) most probably include abnormalities of the genital tract, genetic predisposition, hormonal imbalance, altered immune surveillance, inflammatory response and abnormal regulation of the endometrial cells. The mediators that contribute to survival and progression of endometriosis are likely involved in the development of the symptoms of this process. Genomic studies have started to delineate the wide array of mediators involved and the complex genetic background required in the development of endometriosis. This review summarizes our current knowledge regarding the pathogenesis of endometriosis, including progress made with transgenic animals, and a clinical perspective on the diagnosis and management of this common process.

Original languageEnglish
Pages (from-to)595-619
Number of pages25
JournalFrontiers in Bioscience
Volume11
Issue number1 P.447-888
DOIs
Publication statusPublished - Feb 24 2006

Keywords

  • Endometriosis
  • Endometrium
  • Estrogen
  • Immune Surveillance
  • Inflammation
  • MIF
  • Macrophage Migration Inhibitory Factor
  • Review
  • Transgenic

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Garai, J., Molnar, V., Varga, T., Koppan, M., Torok, A., & Bodis, J. (2006). Endometriosis: Harmful survival of an ectopic tissue. Frontiers in Bioscience, 11(1 P.447-888), 595-619. https://doi.org/10.2741/1821