Endogenous urinary steroids in postmenopausal women with epithelial ovarian cancer

Anita Bufa, Viktória Poór, András Bálint, Szilárd Molnár, Sára Jeges, László Pótó, Péter Gocze, Ferenc Kilár

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Abstract

The profile of endogenous steroids in the presence of ovarian cancer was studied. Urine samples from 15 postmenopausal women with epithelial ovarian cancer and ten age-matched healthy women were collected for 24 h. The concentration of 23 androgen, progesterone and corticoid metabolites in the urine samples of the two groups were quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring. In the course of the urinary steroid determination we observed changes in the steroid profiles in the diseases examined compared to the same age and same sex control groups. Profiling urinary steroids has to give a comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. The concentrations of An, Et, 11-OH-An, 11-OH-Et, Δ5-PT, THE, THF, α-CL, β-CL and α-C were not significantly different in the two groups. The concentrations of DHEA, 16-OHD, PD, PT, Δ5-AT, THA, THB, aTHB and aTHF were significantly higher in the postmenopausal women with epithelial ovarian cancer than in the controls. The levels of Δ5-PD, THS, 11-OPT and F could not be determined because the concentrations of these compounds were below the limit of detection or the lower limit of quantification. The changes in the levels of single metabolites point out the important role of steroid groups, thus providing help in the recognition and treatment of diseased states.

Original languageEnglish
Pages (from-to)S131-S135
JournalChromatographia
Volume68
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Oct 1 2008

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Keywords

  • Androgens, progesterone and corticoids
  • Gas chromatography-mass spectrometry
  • Ovarian cancer
  • Urinary concentration

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Bufa, A., Poór, V., Bálint, A., Molnár, S., Jeges, S., Pótó, L., Gocze, P., & Kilár, F. (2008). Endogenous urinary steroids in postmenopausal women with epithelial ovarian cancer. Chromatographia, 68(SUPPL. 1), S131-S135. https://doi.org/10.1365/s10337-008-0710-7