Endogén nociceptin-szint vizsgálatok ischémiás stroke-ban: a nociceptinerg rendszer kapcsolata a szerotonerg rendszerrel.

Translated title of the contribution: Endogenous nociceptin level in ischemic stroke: connection to serotonin system

Kornélia Tekes, Mónika Hantos, György Bátor, Melinda Gyenge, Rudolf Laufer, András Folyovich

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Particular role of the heptadecapeptide nociceptin (orphanin FQ), the endogenous agonist of the NOP receptor, has been widely demonstrated in the regulation of pain sensation and anxiety-related behavior. In our best knowledge this is the first study reporting plasma nociceptin levels in 26 acute stroke and 6 transiens ischemic attack (TIA) patients. We have found significantly elevated plasma nociceptin levels in all the three groups of patients studied (stroke influencing the carotis or the lacunar region and TIA). We suggest that elevated plasma nociceptin level is the consequence of stroke as in the group of patients recovered from previous stroke was found similar the control value. Plasma serotonin level was found non-significantly decreased in patients with stroke influencing the lacunar region and TIA patients. However the plasma 5-hydroxy-indoleacetic acid (5HIAA) levels were found significantly elevated in patient groups with stroke influencing both the carotis and the lacunar regions. Data may serve as further evidence for the serotonergic dysregulation in stroke.

Original languageHungarian
Pages (from-to)53-59
Number of pages7
JournalNeuropsychopharmacologia Hungarica : a Magyar Pszichofarmakológiai Egyesület lapja = official journal of the Hungarian Association of Psychopharmacology
Volume8
Issue number2
Publication statusPublished - Jun 2006

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

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