Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD)

Zsolt Barta, Gabor G. Szabo, Geza Bruckner, Gyula Szegedi

Research output: Contribution to journalArticle

21 Citations (Scopus)


Background: Lipoid pneumonia is a rare pulmonary disease, a form of pneumonia that has no classical radiological appearance, thus it can imitate other lung diseases. Lipoid pneumonia is usually classified into two major groups, depending on whether the source of oil/fat in the respiratory tract is from an exogenous or endogenous source. Undifferentiated connective tissue disease is a term used by rheumatologist to define a group of diffuse connective tissue disorders that lack definitive characteristics of any particular well-defined disorder. Material and Methods: A case study is reported of concomitant undifferentiated connective tissue disease and endogenous lipoid pneumonia. Results: Histologically the macrophages appeared filled with lipid and were similar to atherosclerotic foam cell macrophages. Antibiotic and antimycotic treatments were ineffective. However, with concomitant steroid treatment, the patient exhibited absence of lung infiltration as well as other symptoms and was discharged. Therefore it is concluded that the lipoid pneumonia was steroid dependent. Conclusion: Since the patient's condition responded to steroid treatment, and it is clear that steroids inhibit phospholipase activity, the authors speculate that the subsequent decreased endoperoxide production may diminish lipid uptake by macrophages via decreasing modification of LDL or other lipid sources.

Original languageEnglish
Pages (from-to)134-136
Number of pages3
JournalMedical Science Monitor
Issue number1
Publication statusPublished - Feb 19 2001


  • Lipoid pneumonia
  • Macrophage
  • Steroid
  • UCTD

ASJC Scopus subject areas

  • Medicine(all)

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