Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD)

Z. Barta, Gabor G. Szabo, Geza Bruckner, G. Szegedi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Lipoid pneumonia is a rare pulmonary disease, a form of pneumonia that has no classical radiological appearance, thus it can imitate other lung diseases. Lipoid pneumonia is usually classified into two major groups, depending on whether the source of oil/fat in the respiratory tract is from an exogenous or endogenous source. Undifferentiated connective tissue disease is a term used by rheumatologist to define a group of diffuse connective tissue disorders that lack definitive characteristics of any particular well-defined disorder. Material and Methods: A case study is reported of concomitant undifferentiated connective tissue disease and endogenous lipoid pneumonia. Results: Histologically the macrophages appeared filled with lipid and were similar to atherosclerotic foam cell macrophages. Antibiotic and antimycotic treatments were ineffective. However, with concomitant steroid treatment, the patient exhibited absence of lung infiltration as well as other symptoms and was discharged. Therefore it is concluded that the lipoid pneumonia was steroid dependent. Conclusion: Since the patient's condition responded to steroid treatment, and it is clear that steroids inhibit phospholipase activity, the authors speculate that the subsequent decreased endoperoxide production may diminish lipid uptake by macrophages via decreasing modification of LDL or other lipid sources.

Original languageEnglish
Pages (from-to)134-136
Number of pages3
JournalMedical Science Monitor
Volume7
Issue number1
Publication statusPublished - 2001

Fingerprint

Connective Tissue Diseases
Pneumonia
Steroids
Macrophages
Lipids
Lung Diseases
Foam Cells
Phospholipases
Rare Diseases
Respiratory System
Connective Tissue
Oils
Therapeutics
Fats
Anti-Bacterial Agents
Lung

Keywords

  • Lipoid pneumonia
  • Macrophage
  • Steroid
  • UCTD

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD). / Barta, Z.; Szabo, Gabor G.; Bruckner, Geza; Szegedi, G.

In: Medical Science Monitor, Vol. 7, No. 1, 2001, p. 134-136.

Research output: Contribution to journalArticle

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