Endocrine characteristics of polycystic ovary syndrome (PCOS)

A. Szilágyi, I. Szabó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is probably the most prevalent endocrinopathy in women and the most common cause of anovulatory infertility. Patients with PCOS have clinical and biochemical features consistent with the ultrasound diagnosis and they are likely to face the problems of hyperandrogenism, subfertility and recurrent miscarriage. The aim of the present review is to summarize our present knowledge on the hormonal background of this very prevalent syndrome and to give some clinical examples how the present knowledge can be applied to treat PCOS patients according to their current problem, such as menstrual cycle disorder, hirsutism, infertility or to prevent late consequences as diabetes mellitus. The etiology and pathogenesis of PCOS is still a matter of controversies, but it is apparent that inappropriate gonadotropin secretion, obesity, hyperinsulinism and insulin resistance are the major determining factors in the development of ovarian hyperandrogenism an chronic anovulation. Reversal of insulin resistance in PCOS constitutes the fundamental goal in the management of hyperandrogenic anovulatory infertility and in the prevention of long-term consequences. The value of the insulin sensitizer metformin therapy awaits further evaluation and it should be integrated in the spectrum of therapeutical options that include the discussed surgical methods and GnRH analogues as well.

Original languageEnglish
Pages (from-to)694-700
Number of pages7
JournalIndian Journal of Experimental Biology
Volume41
Issue number7
Publication statusPublished - Jul 1 2003

Fingerprint

Polycystic Ovary Syndrome
Insulin
Infertility
Hyperandrogenism
Metformin
Insulin Resistance
Medical problems
Gonadotropins
Gonadotropin-Releasing Hormone
Anovulation
Habitual Abortion
Ultrasonics
Hirsutism
Hyperinsulinism
Menstrual Cycle
Diabetes Mellitus
Obesity

Keywords

  • Anovulatory infertility
  • Endocrinopathy
  • PCOS
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Bioengineering

Cite this

Endocrine characteristics of polycystic ovary syndrome (PCOS). / Szilágyi, A.; Szabó, I.

In: Indian Journal of Experimental Biology, Vol. 41, No. 7, 01.07.2003, p. 694-700.

Research output: Contribution to journalArticle

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