Endocannabinoids as cardiovascular modulators

George Kunos, Zoltán Járai, Sándor Bátkai, Sravan Kumar Goparaju, Edward J.N. Ishac, Jie Liu, Lei Wang, Jens A. Wagner

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104 Citations (Scopus)

Abstract

Cannabinoids, the bioactive constituents of the marijuana plant and their synthetic and endogenous analogs cause not only neurobehavioral, but also cardiovascular effects. The most important component of these effects is a profound decrease in blood pressure and heart rate. Although multiple lines of evidence indicate that the hypotensive and bradycardic effects of anandamide and other cannabinoids are mediated by peripherally located CB1 cannabinoid receptors, anandamide can also elicit vasodilation in certain vascular beds, which is independent of CB1 or CB2 receptors. Possible cellular mechanisms underlying these effects and the cellular sources of vasoactive anandamide are discussed. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)159-168
Number of pages10
JournalChemistry and Physics of Lipids
Volume108
Issue number1-2
DOIs
Publication statusPublished - Dec 12 2000

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Keywords

  • Cannabinoids
  • Cardiovascular effects
  • Marijuana

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology

Cite this

Kunos, G., Járai, Z., Bátkai, S., Goparaju, S. K., Ishac, E. J. N., Liu, J., Wang, L., & Wagner, J. A. (2000). Endocannabinoids as cardiovascular modulators. Chemistry and Physics of Lipids, 108(1-2), 159-168. https://doi.org/10.1016/S0009-3084(00)00194-8