Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

Research output: Contribution to journalArticle

357 Citations (Scopus)

Abstract

Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy, but its psychotropic effect has reduced its usage in recent medical practice. However, renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders.

Original languageEnglish
Pages (from-to)923-930
Number of pages8
JournalNature Medicine
Volume14
Issue number9
DOIs
Publication statusPublished - Sep 2008

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Endocannabinoids
Electric circuit breakers
Cannabis
Synapses
History of Medicine
Neocortex
Nervous System Diseases
Human Body
Epilepsy
Spinal Cord
Central Nervous System
Communication
Neurology
Pain
Medicine
Machinery
Therapeutics
Modulation
Feedback

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. / Katona, I.; Freund, T.

In: Nature Medicine, Vol. 14, No. 9, 09.2008, p. 923-930.

Research output: Contribution to journalArticle

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