Enantiospecific synthesis and absolute configuration of β-lactam, intermediates from 2-amino-1-phenyl-1,3-propanediols

Tamas E. Gunda, Siegfried Vieth, Katalin E. Kövér, Ferenc Sztaricskai

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The aldimines derived from (1S,2S)-2-amino-1-phenyl-1,3-propanediols as chiral starting materials were used to prepare cis-β-lactams (3, 4) via the Staudinger-reaction. High diastereoselectivity was reached only with large silyl protecting groups. The 6 oxazine derivative was obtained when using butyryl chloride as ketene precursor.

Original languageEnglish
Pages (from-to)6707-6710
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number46
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Enantiospecific synthesis and absolute configuration of β-lactam, intermediates from 2-amino-1-phenyl-1,3-propanediols'. Together they form a unique fingerprint.

  • Cite this