Enantioselective michael addition of malonates to enones

P. Bakó, Tamás Nemcsok, Zsolt Rapi, György Keglevich

Research output: Contribution to journalReview article

Abstract

Many catalysts were tested in asymmetric Michael additions in order to synthe-size enantioenriched products. One of the most common reaction types among the Michael reactions is the conjugated addition of malonates to enones making it possible to in-vestigate the structure–activity relationship of the catalysts. The most commonly used Michael acceptors are chalcone, substituted chalcones, chalcone derivatives, cyclic enones, while typical donors may be dimethyl, diethyl, dipropyl, diisopropyl, dibutyl, di-tert-butyl and dibenzyl malonates. This review summarizes the most important enantioselective catalysts applied in these types of reactions.

Original languageEnglish
Pages (from-to)746-773
Number of pages28
JournalCurrent Organic Chemistry
Volume24
Issue number7
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • Catalysis
  • Enantioselectivity
  • Malonates
  • Michael addition
  • Substituted chalcones
  • Unsaturated ketones

ASJC Scopus subject areas

  • Organic Chemistry

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