Enantioselective hydrogenation of ketopantolactone using Pt-β-ICN chiral catalyst: Correlation between the solution-state concentration of a nucleophilic β-isocinchonine-ketopantolactone complex and enantioselectivity

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Abstract

Experimental evidence (measured by NMR) is given for the correlation between the solution-state concentration of the nucleophilic 1:1 modifier-substrate complex and the ee on enantioselective hydrogenation of ketopantolactone using Pt-β-isocinchonine chiral catalyst. The relationship displays a saturation-type curve, which may indicate an underlying adsorption process involving the catalytically relevant nucleophilic complex.

Original languageEnglish
Pages (from-to)296-303
Number of pages8
JournalJournal of Catalysis
Volume255
Issue number2
DOIs
Publication statusPublished - Apr 25 2008

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Keywords

  • Enantioselective hydrogenation
  • Intermediate complex
  • Ketopantolactone
  • NMR
  • Organocatalysis
  • Origin of enantioselection
  • Pt-cinchona catalyst

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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