Experimental evidence (measured by NMR) is given for the correlation between the solution-state concentration of the nucleophilic 1:1 modifier-substrate complex and the ee on enantioselective hydrogenation of ketopantolactone using Pt-β-isocinchonine chiral catalyst. The relationship displays a saturation-type curve, which may indicate an underlying adsorption process involving the catalytically relevant nucleophilic complex.
- Enantioselective hydrogenation
- Intermediate complex
- Origin of enantioselection
- Pt-cinchona catalyst
ASJC Scopus subject areas
- Physical and Theoretical Chemistry