Excellent ee's and extremely high activities are obtained in the rhodium-catalyzed hydrogenation of dimethyl itaconate using simple and readily available H8-BINOL based monodentate phosphites. The hydrogenation proceeds efficiently even at a substrate concentration of 5.263 mol L-1 and at a substrate to catalyst ratio (S/C) of 40,000 to give the product in 95.1% yield with up to 96.9% ee.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry