Enantioselective hydrogenation catalyzed by highly active rhodium complexes of chiral phosphites with atropisomeric moieties

Ildikó Gergely, Csaba Hegedüs, Henrik Gulyás, A. Szöllösy, Axel Monsees, Thomas Riermeier, J. Bakos

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Excellent ee's and extremely high activities are obtained in the rhodium-catalyzed hydrogenation of dimethyl itaconate using simple and readily available H8-BINOL based monodentate phosphites. The hydrogenation proceeds efficiently even at a substrate concentration of 5.263 mol L-1 and at a substrate to catalyst ratio (S/C) of 40,000 to give the product in 95.1% yield with up to 96.9% ee.

Original languageEnglish
Pages (from-to)1087-1090
Number of pages4
JournalTetrahedron Asymmetry
Volume14
Issue number9
DOIs
Publication statusPublished - May 2 2003

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Phosphites
Rhodium
Hydrogenation
rhodium
hydrogenation
Substrates
catalysts
Catalysts
products
naphthol BINOL
dimethyl itaconate

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Enantioselective hydrogenation catalyzed by highly active rhodium complexes of chiral phosphites with atropisomeric moieties. / Gergely, Ildikó; Hegedüs, Csaba; Gulyás, Henrik; Szöllösy, A.; Monsees, Axel; Riermeier, Thomas; Bakos, J.

In: Tetrahedron Asymmetry, Vol. 14, No. 9, 02.05.2003, p. 1087-1090.

Research output: Contribution to journalArticle

Gergely, Ildikó ; Hegedüs, Csaba ; Gulyás, Henrik ; Szöllösy, A. ; Monsees, Axel ; Riermeier, Thomas ; Bakos, J. / Enantioselective hydrogenation catalyzed by highly active rhodium complexes of chiral phosphites with atropisomeric moieties. In: Tetrahedron Asymmetry. 2003 ; Vol. 14, No. 9. pp. 1087-1090.
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