Enantioselective hydrogenation catalyzed by highly active rhodium complexes of chiral phosphites with atropisomeric moieties

Ildikó Gergely, Csaba Hegedüs, Henrik Gulyás, Áron Szöllosy, Axel Monsees, Thomas Riermeier, József Bakos

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Abstract

Excellent ee's and extremely high activities are obtained in the rhodium-catalyzed hydrogenation of dimethyl itaconate using simple and readily available H8-BINOL based monodentate phosphites. The hydrogenation proceeds efficiently even at a substrate concentration of 5.263 mol L-1 and at a substrate to catalyst ratio (S/C) of 40,000 to give the product in 95.1% yield with up to 96.9% ee.

Original languageEnglish
Pages (from-to)1087-1090
Number of pages4
JournalTetrahedron Asymmetry
Volume14
Issue number9
DOIs
Publication statusPublished - May 2 2003

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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