Enantiomeric separation of unusual secondary aromatic amino acids

A. Péter, G. Török, G. Tóth, W. Van Den Nest, G. Laus, D. Tourwé, D. W. Armstrong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

High-performance liquid chromatographic and gas chromatographic methods were developed for the separation of unusual secondary aromatic amino acids. Amino acids containing 1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydronorharmane-1-carboxylic acid and 1,2,3,4-tetrahydro-3-carboxy-2-carboline moieties were synthetized in racemic or chiral forms. The high-performance liquid chromatography was carried out either on a teicoplanin-containing chiral stationary phase or on an achiral C18 column. In the latter case the diastereomers of the amino acids formed by precolumn derivatization with the chiral reagents 2,3,3,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate or 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide were separated. The gas chromatographic analyses were based on separation on a Chirasil-L-Val column.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalChromatographia
Volume48
Issue number1-2
DOIs
Publication statusPublished - 1998

Fingerprint

Imino Acids
Aromatic Amino Acids
Gases
Teicoplanin
Amino Acids
Carbolines
High performance liquid chromatography
Carboxylic Acids
Amides
Alanine
Gas Chromatography
High Pressure Liquid Chromatography
Liquids

Keywords

  • Chiral derivatization
  • Column liquid chromatography
  • Enantiomeric separation
  • Gas chromatography
  • Unusual secondary aromatic amino acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Péter, A., Török, G., Tóth, G., Van Den Nest, W., Laus, G., Tourwé, D., & Armstrong, D. W. (1998). Enantiomeric separation of unusual secondary aromatic amino acids. Chromatographia, 48(1-2), 53-58. https://doi.org/10.1007/BF02467516

Enantiomeric separation of unusual secondary aromatic amino acids. / Péter, A.; Török, G.; Tóth, G.; Van Den Nest, W.; Laus, G.; Tourwé, D.; Armstrong, D. W.

In: Chromatographia, Vol. 48, No. 1-2, 1998, p. 53-58.

Research output: Contribution to journalArticle

Péter, A, Török, G, Tóth, G, Van Den Nest, W, Laus, G, Tourwé, D & Armstrong, DW 1998, 'Enantiomeric separation of unusual secondary aromatic amino acids', Chromatographia, vol. 48, no. 1-2, pp. 53-58. https://doi.org/10.1007/BF02467516
Péter A, Török G, Tóth G, Van Den Nest W, Laus G, Tourwé D et al. Enantiomeric separation of unusual secondary aromatic amino acids. Chromatographia. 1998;48(1-2):53-58. https://doi.org/10.1007/BF02467516
Péter, A. ; Török, G. ; Tóth, G. ; Van Den Nest, W. ; Laus, G. ; Tourwé, D. ; Armstrong, D. W. / Enantiomeric separation of unusual secondary aromatic amino acids. In: Chromatographia. 1998 ; Vol. 48, No. 1-2. pp. 53-58.
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