Enantiomeric separation of racemic isoflavanones and related compounds on (+)-poly(triphenylmethyl methacrylate)-coated silica gel

Sándor Antus, Rudolf Bauer, Ágnes Gottsegen, Hermann Lotter, Otto Seligmann, Hildebert Wagner

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Abstract

(+)-Poly(triphenylmethyl methacrylate)-coated silica gel [Chiralpack OT(+)] was used for the separation of enantiomers of racemic isoflavanone, homoisoflavanone, isoflavan and 2-benzyltetralone derivatives. All the enantiomers of the above-mentioned compounds were separable. The efficiency of the separation depended on both the skeleton and substitution pattern of the racemic compounds. A relation between the number and polarity of substituents in the aromatic rings and the resolution and separation factors was observed.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalJournal of Chromatography A
Volume603
Issue number1-2
DOIs
Publication statusPublished - Jun 19 1992

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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