Enantiomeric separation of optically active pyridazinone derivatives by chiral HPLC

Margit Bidló-Iglóy, P. Mátyus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Several 4,5-disubstituted 3(2H)-pyridazinone derivatives containing 2-hydroxymethylpyrrolidino moiety as a chiral building block were synthetized. Separation of enantiomers was carried out by chiral HPLC on Chiralcel OJ and OF columns. Mobile phases consisted of hexane, ethanol and 2-propanol. Chiralcel OJ column was capable of separating most of the enantiomeric pairs. For one type of compound, Chiralcel OF column was used for separation.

Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume19
Issue number3-4
DOIs
Publication statusPublished - Mar 1 1999

Fingerprint

2-Propanol
Hexanes
Ethanol
High Pressure Liquid Chromatography
Derivatives
Enantiomers

Keywords

  • Chiral HPLC
  • Chiralcel columns
  • Pyridazinone derivatives

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

Enantiomeric separation of optically active pyridazinone derivatives by chiral HPLC. / Bidló-Iglóy, Margit; Mátyus, P.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 19, No. 3-4, 01.03.1999, p. 487-490.

Research output: Contribution to journalArticle

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