Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins

Krisztina Németh, Gábor Tárkányi, Erzsébet Varga, Tímea Imre, Réka Mizsei, Róbert Iványi, Júlia Visy, Julianna Szemán, László Jicsinszky, Lajos Szente, Miklós Simonyi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Capillary electrophoresis (CE) methods for chiral resolution of five antimalarial drugs (primaquine, tafenoquine, mefloquine, chloroquine and quinacrine) were developed by using a wide selection of neutral and anionic cyclodextrin (CD) derivatives. The use of sulfobutyl-β-CD and carboxymethyl-β-CD (CMBCD) resulted in good resolution of quinacrine and tafenoquine, respectively. New results are presented for resolutions of chloroquine and mefloquine. Application of carboxyalkyl- and sulfobutyl-CD derivatives provided improved resolution for primaquine. The impurity in primaquine sample detected by CE was identified as quinocide by MS and NMR. CMBCD provided not only the best separation of primaquine from quinocide but also the simultaneous complete resolution of both compounds.

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume54
Issue number3
DOIs
Publication statusPublished - Feb 20 2011

Keywords

  • Antimalarial drugs
  • Cyclodextrin modified capillary zone electrophoresis
  • Drug impurity
  • Enantioselective analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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