[Emotional state variations in rats during recall of passive avoidance reactions after neurotensin administration into nucleus accumbens of the brain].

E. V. Miroshnichenko, A. V. Stavrovskaia, N. P. Shugalev, L. Lénárd, G. Hartmann

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Behavioral effects of neurotensin administration into the nucleus accumbens were studied in rats with neurotoxic lesions of serotoninergic structures of the dorsal raphe nucleus or periaqueductal grey matter. Changes in recall of passive avoidance conditioned reactions and aftereffects of painful stimulation in the locomotor activity were studied in the "open field" and elevated plus-maze and T-maze tests. The toxin administration into the dorsal raphe nucleus did not impair the recall of the passive avoidance reactions, but enhanced the oppressive aftereffects of painful stimulation, which can specify the development of anxiety in rats. The toxin administration into the periaqueductal grey matter had an opposite effect, which can be considered as a manifestation of the panic state. Neurotensin weakened the above mentioned effects of the toxin and, depending on the evoked emotional disorders, produced the anxiolytic or antipanic effects.

Original languageEnglish
Pages (from-to)704-711
Number of pages8
JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume60
Issue number6
Publication statusPublished - Nov 2010

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Neurotensin
Periaqueductal Gray
Nucleus Accumbens
Panic
Anti-Anxiety Agents
Brain
Locomotion
Anxiety
Dorsal Raphe Nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

[Emotional state variations in rats during recall of passive avoidance reactions after neurotensin administration into nucleus accumbens of the brain]. / Miroshnichenko, E. V.; Stavrovskaia, A. V.; Shugalev, N. P.; Lénárd, L.; Hartmann, G.

In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 60, No. 6, 11.2010, p. 704-711.

Research output: Contribution to journalArticle

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