Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells

F. Boldizsár, Gergely Talaber, Mariann Szabo, Domokos Bartis, L. Pálinkás, P. Németh, T. Berki

Research output: Contribution to journalArticle

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Abstract

In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating evidence came to light about the discrepancy in the apoptosis sensitivity and GR expression of thymocytes and other lymphoid cell types. Herein, we attempt to sample the latest information in the field of non-genomic GC signalling in T cells, and correlate it with results from our laboratory. We discuss some aspects of the regulation of thymocyte apoptosis by GCs, paying special interest to the potential role(s) of mitochondrial GR signalling. The interplay between the T cell receptor (TcR) and glucocorticoid receptor (GR) signalling pathways is described in more detail, focusing on ZAP-70, which is a novel target of rapid GC action.

Original languageEnglish
Pages (from-to)521-526
Number of pages6
JournalImmunobiology
Volume215
Issue number7
DOIs
Publication statusPublished - Jul 2010

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Glucocorticoids
T-Lymphocytes
Glucocorticoid Receptors
Thymocytes
Apoptosis
T-Cell Antigen Receptor
Lymphocytes

Keywords

  • Glucocorticoid hormone
  • Mitochondrion
  • Non-genomic effects
  • T cell
  • ZAP-70

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Medicine(all)

Cite this

Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells. / Boldizsár, F.; Talaber, Gergely; Szabo, Mariann; Bartis, Domokos; Pálinkás, L.; Németh, P.; Berki, T.

In: Immunobiology, Vol. 215, No. 7, 07.2010, p. 521-526.

Research output: Contribution to journalArticle

Boldizsár, F. ; Talaber, Gergely ; Szabo, Mariann ; Bartis, Domokos ; Pálinkás, L. ; Németh, P. ; Berki, T. / Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells. In: Immunobiology. 2010 ; Vol. 215, No. 7. pp. 521-526.
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