Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells

Ferenc Boldizsar, Gergely Talaber, Mariann Szabo, Domokos Bartis, Laszlo Palinkas, Peter Nemeth, Timea Berki

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating evidence came to light about the discrepancy in the apoptosis sensitivity and GR expression of thymocytes and other lymphoid cell types. Herein, we attempt to sample the latest information in the field of non-genomic GC signalling in T cells, and correlate it with results from our laboratory. We discuss some aspects of the regulation of thymocyte apoptosis by GCs, paying special interest to the potential role(s) of mitochondrial GR signalling. The interplay between the T cell receptor (TcR) and glucocorticoid receptor (GR) signalling pathways is described in more detail, focusing on ZAP-70, which is a novel target of rapid GC action.

Original languageEnglish
Pages (from-to)521-526
Number of pages6
JournalImmunobiology
Volume215
Issue number7
DOIs
Publication statusPublished - Jul 1 2010

    Fingerprint

Keywords

  • Glucocorticoid hormone
  • Mitochondrion
  • Non-genomic effects
  • T cell
  • ZAP-70

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this