Emerging functions for tuberoinfundibular peptide of 39 residues

Ted B. Usdin, Arpad Dobolyi, Hiroshi Ueda, Miklós Palkovits

Research output: Contribution to journalReview article

30 Citations (Scopus)


Tuberoinfundibular peptide of 39 residues (TIP39), a neuropeptide recently purified from the hypothalamus, appears to be an endogenous ligand for the parathyroid hormone 2 (PTH2) receptor. PTH2 receptors are present in several central nervous system and peripheral areas and are particularly concentrated in the hypothalamus, limbic areas and the outer layers of the spinal cord dorsal horn. TIP39-containing neuronal cell bodies have been identified in the subparafascicular area and the medial paralemniscal nucleus, two brainstem regions that project widely through the entire neuraxis. Treatment of hypothalamic explants with TIP39, and intraventricular injection of the peptide, suggest that it might stimulate hypothalamic-releasing factor secretion. Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number1
Publication statusPublished - Jan 1 2003


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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