Emergency care of patients receiving non-vitamin K antagonist oral anticoagulants

J. W. Eikelboom, S. Kozek-Langenecker, A. Exadaktylos, A. Batorova, Z. Boda, F. Christory, I. Gornik, G. Kėkštas, A. Kher, R. Komadina, O. Koval, G. Mitic, T. Novikova, E. Pazvanska, S. Ratobilska, J. Sütt, A. Winder, D. Zateyshchikov

Research output: Contribution to journalReview article

5 Citations (Scopus)


Non-vitamin K antagonist oral anticoagulants (NOACs), which inhibit thrombin (dabigatran) and factor Xa (rivaroxaban, apixaban, edoxaban) have been introduced in several clinical indications. Although NOACs have a favourable benefit-risk profile and can be used without routine laboratory monitoring, they are associated–as any anticoagulant–with a risk of bleeding. In addition, treatment may need to be interrupted in patients who need surgery or other procedures. The objective of this article, developed by a multidisciplinary panel of experts in thrombosis and haemostasis, is to provide an update on the management of NOAC-treated patients who experience a bleeding episode or require an urgent procedure. Recent advances in the development of targeted reversal agents are expected to help streamline the management of NOAC-treated patients in whom rapid reversal of anticoagulation is required.

Original languageEnglish
Pages (from-to)645-656
Number of pages12
JournalBritish Journal of Anaesthesia
Issue number4
Publication statusPublished - Apr 2018


  • anticoagulants
  • coagulation monitoring
  • emergencies
  • haemorrhage
  • reversal

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Eikelboom, J. W., Kozek-Langenecker, S., Exadaktylos, A., Batorova, A., Boda, Z., Christory, F., Gornik, I., Kėkštas, G., Kher, A., Komadina, R., Koval, O., Mitic, G., Novikova, T., Pazvanska, E., Ratobilska, S., Sütt, J., Winder, A., & Zateyshchikov, D. (2018). Emergency care of patients receiving non-vitamin K antagonist oral anticoagulants. British Journal of Anaesthesia, 120(4), 645-656. https://doi.org/10.1016/j.bja.2017.11.082