Emergence of VIM-4 metallo-β-lactamase-producing Klebsiella pneumoniae ST15 clone in the Clinical Centre University of Pécs, Hungary

S. Melegh, K. Kovács, T. Gám, A. Nyul, B. Patkó, A. Tóth, I. Damjanova, G. Mestyán

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Since November 2009 carbapenemase-producing Klebsiella pneumoniae isolates have been detected in increasing numbers at the Clinical Centre University of Pécs. Molecular typing was performed for 102 clinical isolates originating from different time periods and various departments of the Clinical Centre. Pulsed-field gel electrophoresis revealed the predominance of a single clone (101/102), identified as sequence type ST15. PCR and sequencing showed the presence of blaCTX-M-15 and blaVIM-4 genes. The blaVIM-4 was located on a class 1 integron designated In238b. To our knowledge, this is the first description of a blaVIM-4 gene in the predominant CTX-M-15 extended spectrum β-lactamase-producing Hungarian Epidemic Clone/ST15.

Original languageEnglish
JournalClinical Microbiology and Infection
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Hungary
Klebsiella pneumoniae
Clone Cells
Integrons
Molecular Typing
Pulsed Field Gel Electrophoresis
Genes
Polymerase Chain Reaction
galantide
carbapenemase

Keywords

  • Carbapenemase
  • In238b
  • Klebsiella pneumoniae
  • Sequence type 15
  • VIM-4

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Emergence of VIM-4 metallo-β-lactamase-producing Klebsiella pneumoniae ST15 clone in the Clinical Centre University of Pécs, Hungary. / Melegh, S.; Kovács, K.; Gám, T.; Nyul, A.; Patkó, B.; Tóth, A.; Damjanova, I.; Mestyán, G.

In: Clinical Microbiology and Infection, Vol. 20, No. 1, 01.2014.

Research output: Contribution to journalArticle

Melegh, S. ; Kovács, K. ; Gám, T. ; Nyul, A. ; Patkó, B. ; Tóth, A. ; Damjanova, I. ; Mestyán, G. / Emergence of VIM-4 metallo-β-lactamase-producing Klebsiella pneumoniae ST15 clone in the Clinical Centre University of Pécs, Hungary. In: Clinical Microbiology and Infection. 2014 ; Vol. 20, No. 1.
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