Emergence of multireassortant bluetongue virus serotype 4 in Hungary

Ákos Hornyák, Péter Malik, Szilvia Marton, Renáta Dóró, Daniel Cadar, K. Bányai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The genome sequence and the phylogenetic relationships of a serotype 4 bluetongue virus (BTV-4) emerged during 2014 in Hungary are described in this study. Genome segment 2 encoding the major neutralization antigen, VP2, shared moderate sequence similarity (nt, ≤94.3%) with the corresponding gene of contemporary and historic homotypic bluetongue viruses, whereas genome segments S1, S4, S5, S7-S10 were typically more closely related to the cognate genes of heterotypic isolates. Importantly, in many gene phylogenies the Hungarian BTV-4 strain showed genetic relationship to BTV strains identified in outbreaks in the western Mediterranean basin. Our results indicate the identified Hungarian bluetongue virus strain evolved through reassortment involving multiple genome segments from various heterotypic bluetongue viruses.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalInfection, Genetics and Evolution
Volume33
DOIs
Publication statusPublished - Jul 1 2015

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Bluetongue virus
Hungary
virus
serotypes
genome
Genome
gene
S 10
ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate
Genes
neutralization
Phylogeny
antigen
Disease Outbreaks
phylogeny
genes
phylogenetics
Antigens
Serogroup
genetic relationships

Keywords

  • Bluetongue
  • Outbreak
  • Phylogenetic analysis
  • Reassortment
  • Recombination
  • Semiconductor sequencing

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Emergence of multireassortant bluetongue virus serotype 4 in Hungary. / Hornyák, Ákos; Malik, Péter; Marton, Szilvia; Dóró, Renáta; Cadar, Daniel; Bányai, K.

In: Infection, Genetics and Evolution, Vol. 33, 01.07.2015, p. 6-10.

Research output: Contribution to journalArticle

Hornyák, Ákos ; Malik, Péter ; Marton, Szilvia ; Dóró, Renáta ; Cadar, Daniel ; Bányai, K. / Emergence of multireassortant bluetongue virus serotype 4 in Hungary. In: Infection, Genetics and Evolution. 2015 ; Vol. 33. pp. 6-10.
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