Emergence of multidrug-resistant clones of Salmonella Infantis in broiler chickens and humans in Hungary

Noémi Nógrády, A. Tóth, Ágnes Kostyák, J. Pászti, B. Nagy

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objectives: The characterization of a Salmonella Infantis strain collection that was set up from isolates of animal and human origin obtained in Hungary in recent years. Methods: All isolates were phage typed. Antimicrobial resistance was tested by the disc diffusion method, while the presence of the antimicrobial resistance genes and class 1 integrons was investigated by PCR. Genetic relatedness of the isolates was tested by PFGE and plasmid profiling. Results: The majority of the isolates representing different parts of Hungary are characterized by phage types 213 and 217 and the nalidixic acid-streptomycin-sulphonamide-tetracycline resistance type. They harbour a class 1 integron with an aadA1 gene in the 855 bp variable region, a tet(A) gene, a >168 kb plasmid and 66% of them represent one genetic clone as determined by XbaI PFGE fingerprinting. Conclusions: It seems that broiler chickens constitute a reservoir for one large and a few smaller multidrug-resistant Salmonella Infantis clones in Hungary, which might have spread to humans through chicken meat.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume60
Issue number3
DOIs
Publication statusPublished - Sep 2007

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Hungary
Salmonella
Integrons
Chickens
Clone Cells
Bacteriophages
Plasmids
Genes
Tetracycline Resistance
Nalidixic Acid
Sulfonamides
Streptomycin
Meat
Polymerase Chain Reaction

Keywords

  • Class 1 integron
  • Multidrug resistance
  • Plasmid

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

Cite this

Emergence of multidrug-resistant clones of Salmonella Infantis in broiler chickens and humans in Hungary. / Nógrády, Noémi; Tóth, A.; Kostyák, Ágnes; Pászti, J.; Nagy, B.

In: Journal of Antimicrobial Chemotherapy, Vol. 60, No. 3, 09.2007, p. 645-648.

Research output: Contribution to journalArticle

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AU - Pászti, J.

AU - Nagy, B.

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