Emergence of extremely high penicillin and cefotaxime resistance and high-level levofloxacin resistance in clinical isolates of Streptococcus pneumoniae in Hungary

Katalin Glatz, Dóra Szabó, György Szabó, Dimitrinka Boriszova, Ferenc Rozgonyi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Oxacillin disc diffusion tests revealed that 36.7% of 327 Hungarian Streptococcus pneumoniae strains from clinical specimens were not penicillin susceptible. Determination of the MICs of penicillin, cefotaxime and levofloxacin for these strains by Etest confirmed that 30 (9.2%), 19 (5.8%) and four to 11 (1.2-3.4%) were fully penicillin-, cefotaxime- and levofloxacin-resistant, respectively. Most had extremely high MICs. Lower respiratory tract strains were more resistant than those from the upper respiratory tract. Levofloxacin-resistant strains were either penicillin intermediate or resistant, but their MICs did not correlate strongly.

Original languageEnglish
Pages (from-to)731-734
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume48
Issue number5
Publication statusPublished - Dec 11 2001

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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